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MDM2 — TGFB1

Text-mined interactions from Literome

Amaral et al., Biosci Rep 2010 : In previous studies, we have demonstrated that the transforming growth factor beta1 induced E2F-1/Mdm2 ( murine double minute 2 ) /p53 apoptotic pathway was an upstream molecular target of UDCA
Araki et al., J Clin Invest 2010 (Breast Neoplasms) : TGF-beta1 induced expression of human Mdm2 correlates with late-stage metastatic breast cancer ... Whether TGF-beta1 signaling induces Hdm2 expression leading to HDM2 mediated destabilization of p53 has not been investigated ... Additionally, TGF-beta1 expression led to Smad3 activation and murine double minute 2 (Mdm2) expression in murine mammary epithelial cells during epithelial-to-mesenchymal transition ( EMT ) ... Furthermore, histological analyses of human breast cancer samples demonstrated that approximately 65 % of late-stage carcinomas were positive for activated Smad3 and HDM2, indicating a strong correlation between TGF-beta1 mediated induction of HDM2 and late-stage tumor progression