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INS — NEUROD1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shinozuka et al., Biochem Biophys Res Commun 2001
:
Altered expression of HES-1,
BETA2/NeuroD , and PDX-1 is
involved in impaired
insulin synthesis induced by glucocorticoids in HIT-T15 cells
Kaneto et al., J Biol Chem 2002
:
In HeLa and HepG2 cells c-Myc exerted a suppressive effect on the
insulin promoter activity only in the
presence of
NeuroD/BETA2 but not PDX-1
Noguchi et al., Cell Transplant 2006
:
NeuroD was the most effective
inducer of
insulin expression in primary duct cells
Andrali et al., J Biol Chem 2007
(Chronic Disease...) :
Consistent with these data, treatment of MIN6 cells with O- ( 2-acetamido-2-deoxy-d-glucopyranosylidene ) -amino N-phenylcarbamate, an inhibitor of O-GlcNAcase, causes
Neuro-D1 localization to the nucleus and
induction of
insulin gene expression even on low glucose
Saitoh et al., Diabetes Res Clin Pract 2007
:
Forced expression of
NeuroD1 gene by adenoviral vector in these cells
restored the expression of
insulin
Muniappan et al., BMC physiology 2007
:
Expression of either human insulin or the beta cell specific transcription factors PDX-1,
NeuroD1 and MafA in the Hepa1-6 cell line or primary liver cells via adenoviral gene transfer,
results in production and secretion of
insulin
Han et al., Mol Cell Neurosci 2008
:
Among them, insulin and insulin-like growth factor (IGF) family are found to promote the neuronal differentiation of NPCs. Akt activation has been indicated to be responsible for the
insulin/IGF-I induced
neuronal differentiation ... In this study, we have demonstrated that mTOR is involved in the
insulin induced
neuronal differentiation
Nagaya et al., J Endocrinol 2009
:
Transduced expression of PDX-1,
NEUROD or PDX-1/VP16
led to expression of not only
INS but also GLUT2 and prohormone convertase 1 and 2
Wilson et al., Stem Cells 2009
:
We explored this possibility by determining whether ectopic expression of transcription factors known to induce transcription of this gene in beta cells, pancreatic and duodenal homeobox factor 1 ( Pdx1 ), V-maf musculoaponeurotic fibrosarcoma oncogene homolog A ( Mafa ), and
neurogenic differentiation 1 (Neurod1) , would
activate INS gene expression in long-term hIPC cultures
You et al., Diabetes & metabolism journal 2011
:
The adenovirus mediated overexpression of PDX-1,
BETA2/NeuroD and MafA
induced insulin gene expression in NPCCs, but not in adult pig pancreatic cells
Zhang et al., J Cell Physiol 2012
:
Ectopic expression of INSM1 directly
induces insulin , Pax6, and Nkx6.1 expression, whereas Pdx-1 and
NeuroD1 were slightly suppressed by INSM1
Zhou et al., Cells Tissues Organs 2013
:
Expression of MAFA was sufficient to induce insulin mRNA expression in nhpAFS cell lines, whereas a combination of MAFA, PDX1 and NGN3 further induced
insulin expression, and also
induced the expression of other important endocrine cell genes such as glucagon,
NEUROD1 , NKX2.2, ISL1 and PCSK2
Xu et al., Biochem J 1995
:
Ethanol either abolished or severely muted the short- and long-term insulin mediated upregulation of NTP expression, and substantially reduced
insulin mediated
neuronal differentiation
Dikic et al., Curr Biol 1994
:
PC12 cells overexpressing the insulin receptor undergo
insulin dependent
neuronal differentiation