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CASP8 — TNFRSF10A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CASP8 → Complex of TNFRSF10A-TNFSF10 (increases, TNFRSF10A/TNFSF10 Activity)
  
  Evidence: Similarly, all- trans-retinoic acid (ATRA) induces TRAIL production and triggers autocrine induction of apoptosis in acute promyelomonocytic leukemia (APML) cells that harbor the RAR?-PML fusion protein resulting from t(15;17) chromosomal translocations (Altucci et al., 2001).
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: Caspase 3 (CASP3) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR4/5/Caspase 8/Caspase 10 complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10) → APO-2L (TNFSF10) (modification, collaborate)
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR4/5/Caspase 8/Caspase 10 complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: APO-2L (TNFSF10) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Tran et al., J Biol Chem 2001, Miyazaki et al., Nat Immunol 2001, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Tran et al., J Biol Chem 2001, Miyazaki et al., Nat Immunol 2001, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CASP8 — TNFRSF10A (physical association, affinity chromatography technology) Guo et al., Blood 2005*
• IRef Biogrid Interaction: CASP8 — TNFRSF10A (physical association, affinity chromatography technology) Sinha et al., J Biol Chem 2004*
• IRef Biogrid Interaction: CASP8 — TNFRSF10A (physical association, affinity chromatography technology) Kaunisto et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: CASP8 — TNFRSF10A (direct interaction, enzymatic study) Kaunisto et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: CASP8 — TNFRSF10A (physical association, affinity chromatography technology) Gonzalvez et al., Mol Cell 2012
• IRef Biogrid Interaction: CASP8 — TNFRSF10A (physical association, affinity chromatography technology) Jin et al., Cell 2009
• IRef Biogrid Interaction: CASP8 — TNFRSF10A (physical association, affinity chromatography technology) MacFarlane et al., J Biol Chem 1997
• IRef Hprd Interaction: Complex of 17 proteins MacFarlane et al., J Biol Chem 1997
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Sprick et al., Immunity 2000
• IRef Hprd Interaction: CASP8 — TNFRSF10A (in vivo) Söderström et al., J Immunol 2002*
• IRef Intact Interaction: Complex of CASP8-SQSTM1-TNFRSF10A (colocalization, confocal microscopy) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of CASP8-SQSTM1-TNFRSF10B-TNFRSF10A (association, anti bait coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of 21 proteins (association, anti bait coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of CASP8-RIPK1-TNFRSF10A-TNFRSF10B-FADD-CFLAR (association, anti bait coimmunoprecipitation) Rébé et al., Blood 2007
• IRef Intact Interaction: Complex of CASP8-TNFRSF10A-FADD (association, anti bait coimmunoprecipitation) Pavet et al., Cancer Res 2010
• IRef Intact Interaction: Complex of FADD-CASP8-TNFRSF10B-TNFRSF10A (association, anti bait coimmunoprecipitation) Pavet et al., Cancer Res 2010
• IRef Intact Interaction: Complex of 16 proteins (association, anti tag coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: CASP8 — TNFRSF10A (physical association, anti bait coimmunoprecipitation) Fu et al., Oncogene 2012*
• IRef Intact Interaction: CASP8 — TNFRSF10A (colocalization, confocal microscopy) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of FADD-TNFSF10-FADD-TNFSF10-TNFRSF10A-CASP8-TNFRSF10A-CASP8 (association, pull down) Sprick et al., Immunity 2000
• IRef Ophid Interaction: CASP8 — TNFRSF10A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CASP8 — TNFRSF10A (aggregation, confirmational text mining) Söderström et al., J Immunol 2002*

Text-mined interactions from Literome