Venuprasad et al., Nat Immunol 2008
(Disease Models, Animal...) :
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
Liu et al., Ernst Schering Foundation symposium proceedings 2008
(Hypersensitivity) :
Here we provide evidence that Itch is involved in the regulation of transforming growth factor ( TGF ) -beta signaling in naïve T cells and TGF-beta induced expression of the transcription factor Foxp3 , a master regulator in regulatory T cells
Su et al., Semin Immunopathol 2010
:
Recent evidence indicates that Itch is involved in TGF-beta induced Foxp3 expression and Treg regulated airway inflammation, thus identifying a ubiquitin dependent pathway in modulating Tregs