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KIT — MAPK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → Complex of GRB2-KIT (increases, GRB2/KIT Activity) Rönnstrand et al., Cell Mol Life Sci 2004*
  Evidence: The adapter protein Grb2 can directly associate with phosphorylated Y703 and Y936 in c-Kit

Text-mined interactions from Literome

Tsao et al., Cancer 2003 (Hypopigmentation...) : The signal transduction mechanism currently is believed to involve SCF ligand binding of KIT and downstream activation of MAP kinase ( Erk-2 )
Zhu et al., Oncogene 2007 (Gastrointestinal Stromal Tumors) : Activated signaling intermediates were identified by immunoaffinity purification of tyrosine phosphorylated proteins in GIST cells before and after treatment with KIT inhibitors, and these analyses show that GRB2, SHC, CBL and MAPK activation are largely KIT dependent in GISTs, whereas PI3-K, STAT1 and STAT3 activation are partially KIT dependent