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CHKA — MAPK1
Text-mined interactions from Literome
Zagozdzon et al., Cell Signal 2006
(MAP Kinase Signaling System) :
In this work, we compared the
effect of
CHK versus Csk on
MAPK signaling and elucidated the signaling pathway mediated by CHK leading to the activation of Erk1/2 ... Exogenous expression of wild-type
CHK , but not Csk or a dead-kinase mutant of CHK,
resulted in enhanced
Erk1/2 phosphorylation in PC12 cells
Yalcin et al., Oncogene 2010
(Neoplasms, Experimental) :
Selective inhibition of
choline kinase simultaneously
attenuates MAPK and PI3K/AKT signaling
Poehlmann et al., Pathol Res Pract 2010
(Neoplasms) :
Importantly, as current evidence also suggests a role of MAPK 's ( mitogen activated protein kinases ) in cell cycle checkpoint control, we describe in this review both the
ATR/ATM-Chk1/Chk2 signaling pathways as well as the
regulation of cell cycle checkpoints by
MAPK 's as molecular mechanisms in DDR, and how their dysfunction is related to cancer development