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CDKN1A — PTEN
Text-mined interactions from Literome
Choi et al., Glycobiology 2006
(Colorectal Neoplasms) :
On the contrary, suppression of
PTEN levels by RNA interference
restores the enhanced expression of p53 dependent
p21 ( WAF1 ) and p53 independent p27 ( kip1 ) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3
Selvendiran et al., J Biol Chem 2007
(Ovarian Neoplasms) :
Suppression of
PTEN expression with siRNA significantly
reduced the p53 and
p21 levels and activated Akt phosphorylation at Ser ( 473 ) and Thr ( 308 ), resulting in decreased apoptosis and increased cell survival
Park et al., Int J Radiat Oncol Biol Phys 2008
(Carcinoma, Non-Small-Cell Lung...) :
Endogenous wild-type PTEN containing NCI-H460 cells were treated with PTEN-specific siRNA and then irradiated with gamma-IR : however reduced
PTEN levels did not
induce cell-cycle arrest or
p21 expression
Zheng et al., J Cell Biochem 2010
(Stomach Neoplasms) :
Suppression of
PTEN expression with siRNA significantly
reduced the p53 and
p21 levels and activated Akt, resulting in decreased apoptosis and increased cell survival
Luo et al., Mol Cell Biochem 2013
(Airway Remodeling...) :
Moreover, overexpression of
PTEN could
induce ASMCs arrested in the G0/G1 phase through the downregulation of Cyclin D1 and upregulation of
p21 expressions