Yamada et al., J Dent Res 2006
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In contrast, bone morphogenetic protein-2 (BMP-2) enhanced PLAP-1 expression ... Up-regulation of PLAP-1 expression by BMP-2 was confirmed at the protein level when PDL cells were immunostained with anti-PLAP-1 polyclonal antibody
Tomoeda et al., Biochem Biophys Res Commun 2008
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PLAP-1/asporin inhibits activation of BMP receptor via its leucine-rich repeat motif ... Recombinant PLAP-1/asporin inhibited BMP-2 induced cytodifferentiation of PDL cells and competitively prevented BMP-2 from binding to the BMP receptor-IB ( BMPR-IB ), resulting in inhibition of BMP dependent activation of Smad proteins ... Our findings indicate that PLAP-1/asporin inhibits BMP-2 induced differentiation of PDL cells resulting from inactivation of the BMP-2 signaling pathway and that LRR, especially LRR5 of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 interaction