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CYLD — TRAF6

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: CYLD → TRAF2/TRAF6 (protein-protein, inhibition)
• WikiPathways Regulation of toll-like receptor signaling pathway: CYLD → TRAF6 (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CYLD — TRAF6 (direct interaction, enzymatic study) Bremm et al., Nature structural & molecular biology 2010
• IRef Biogrid Interaction: CYLD — TRAF6 (direct interaction, enzymatic study) Kovalenko et al., Nature 2003
• IRef Hprd Interaction: CYLD — TRAF6 (in vitro) Kovalenko et al., Nature 2003, Yoshida et al., J Biol Chem 2005*
• IRef Hprd Interaction: CYLD — TRAF6 (in vivo) Kovalenko et al., Nature 2003, Yoshida et al., J Biol Chem 2005*
• IRef Innatedb Interaction: CYLD — TRAF6 (unknown, -) Jin et al., J Clin Invest 2008*

Text-mined interactions from Literome

Yoshida et al., J Biol Chem 2005 (Inflammation) : CYLD in turn leads to the inhibition of TRAF6 and TRAF7 likely via a deubiquitination dependent mechanism
Jin et al., J Clin Invest 2008 (Bone Resorption...) : Furthermore, CYLD negatively regulated RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events