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DOCK2 — RAC3
Text-mined interactions from Literome
Sanui et al., Immunity 2003
:
We show here that
DOCK2 is
essential for TCR mediated
Rac activation and immunological synapse formation
Jiang et al., J Exp Med 2005
:
In addition, we found that
DOCK2 is
critical for CD28 mediated
Rac activation and is required for the full activation of alloreactive T cells
Kunisaki et al., J Cell Biol 2006
:
DOCK2 is a
Rac activator that regulates motility and polarity during neutrophil chemotaxis
Nishikimi et al., Science 2009
:
In neutrophils,
Rac activation is primarily
mediated by
DOCK2 , an atypical guanine nucleotide exchange factor
Namekata et al., Proc Natl Acad Sci U S A 2010
:
BDNF induces axonal sprouting through
Dock dependent
Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011
:
Multiple factors confer specific Cdc42 and
Rac protein
activation by
dedicator of cytokinesis ( DOCK ) nucleotide exchange factors
Ippagunta et al., Nat Immunol 2011
:
Thus, ASC shapes adaptive immunity independently of inflammasomes by modulating
Dock2 dependent
Rac activation and actin polymerization in DCs and lymphocytes