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MAP3K3 — MAPK12
Text-mined interactions from Literome
Deacon et al., J Biol Chem 1999
:
We have examined the
regulation by
MEKK3 of
MAPK kinase 7 ( MKK7 ) and MKK6, two novel MAPK kinases specific for JNK and p38, respectively
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Wang et al., J Immunol 2011
(MAP Kinase Signaling System) :
Furthermore, the IL-12/IL-18-driven IFN-? production and MAPK activation in Mekk3-deficient T cells was not affected suggesting that
MEKK3 may selectively
mediate the TCR induced
MAPK signals for IFN-? production