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INSR — PTPN2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Hprd Interaction:
PTPN2
—
INSR
(in vivo)
Galic et al., Mol Cell Biol 2003*, Meng et al., J Biol Chem 2004*, Blanchetot et al., Methods 2005
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IRef Hprd Interaction:
PTPN2
—
INSR
(in vitro)
Galic et al., Mol Cell Biol 2003*, Meng et al., J Biol Chem 2004*, Blanchetot et al., Methods 2005
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IRef Intact Interaction:
INSR
—
PTPN2
(genetic interaction, genetic interference)
Meng et al., J Biol Chem 2004*
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IRef Intact Interaction:
INSR
—
PTPN2
(physical association, anti bait coimmunoprecipitation)
Meng et al., J Biol Chem 2004*
Text-mined interactions from Literome
Xu et al., Cell Biol Int 2007
(Diabetes Mellitus, Experimental) :
Two closely related protein tyrosine phosphatases, PTP1B and
TCPTP both showed abilities to negatively
regulate insulin receptor signaling
Loh et al., Diabetologia 2012
(Diabetes Mellitus, Type 2...) :
PTP1B dephosphorylates the insulin receptor in liver and muscle to regulate glucose homeostasis, whereas
TCPTP regulates
insulin receptor signalling and gluconeogenesis in the liver ... In this study we assessed for the first time the
role of
TCPTP in the regulation of
insulin receptor signalling in muscle ... Thus, despite their high degree of sequence identity, PTP1B and
TCPTP contribute differentially to
insulin receptor regulation in muscle
Zee et al., Mol Cell Biol 2012
(Bone Resorption...) :
Here we show that the
T-cell protein tyrosine phosphatase ( TC-PTP )
regulates insulin receptor phosphorylation in the osteoblast, thus compromising bone resorption and bioactivity of osteocalcin