Gene interactions and pathways from curated databases and text-mining

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NPEPPS — TNF

Text-mined interactions from Literome

Mizokami et al., J Urol 2000 (Disease Progression...) : TNFalpha inhibited the ability of 10-9 M dihydrotestosterone ( DHT ) to induce LNCaP cell proliferation and activation of the prostate specific antigen (PSA) gene promoter
Okamoto et al., Immunopharmacology 2000 : In in vitro experiments using human peripheral blood mononuclear cells ( PBMC ), OK-PSA induced IFN-gamma, interleukin (IL)-2, IL-12, IL-18, tumor necrosis factor (TNF)-alpha and TNF-beta that are generally called `` Th1-type cytokines '' both in protein and in mRNA levels
Cinar et al., Biochem J 2004 (Prostatic Neoplasms) : We observed that activation of NF-kappaB by TNFalpha ( tumour necrosis factor alpha ) inhibited both basal and androgen stimulated PSA expression, and that this down-regulation occurred at the promoter level, as confirmed by the super-repressor IkappaBalpha ( S32A/S36A ), a dominant negative inhibitor of NF-kappaB
Prodanovich et al., Am J Clin Dermatol 2010 (Arthritis, Psoriatic...) : Tumor necrosis factor alpha (TNFalpha) plays a key pathophysiological role in psoriasis and psoriatic arthritis (PsA)
Osiovich et al., Biol Neonate 1995 : In the Indo+TNF group the early TNF induced rise in Psa was blunted compared to the TNF group [ 2.9 +/- 1.2 vs. 3.6 +/- 0.8 kPa ( 22 +/- 3 vs. 27 +/- 6 mm Hg ; p < 0.04 ) ] as were the late decreases in pH and Psa ( p < 0.04 )