◀ Back to STAT3
AKT2 — STAT3
Text-mined interactions from Literome
Alonzi et al., Mol Cell Neurosci 2001
:
To assess the relative importance of these pathways in promoting the survival of cytokine dependent neurons, we conditionally inactivated
STAT3 in mice and
inhibited MEK, PI3K, and
Akt in cultured neurons using pharmacological reagents and by expressing specific inhibitory proteins
Frost et al., Mol Cancer Ther 2002
:
In signaling studies, addition of stem cell factor (SCF) induced phosphorylation of ERK and
Akt by WTKit, and ERK, Akt and
STAT3 by V560GKit, which were all
blocked by Imatinib
Duensing et al., Oncogene 2004
(Gastrointestinal Neoplasms) :
Using GIST in vitro models, we showed that activation of MAPK p42/44,
AKT , and S6K was KIT
dependent , whereas STAT1 and
STAT3 phosphorylation was only partially dependent on KIT activation
Xu et al., Oncogene 2005
(Neoplasms) :
We further demonstrate that
Stat3 regulates expression of
Akt , which is required for growth signal induced HIF-1 upregulation
Shair et al., PLoS Pathog 2007
(Cell Transformation, Neoplastic...) :
The lymphoma cells have deregulated cell cycle markers, and inhibitors of
Akt , NFkappaB, and
Stat3 block the enhanced viability of LMP1 transgenic lymphocytes and lymphoma cells in vitro
Lu et al., Cell Physiol Biochem 2008
:
Inhibition of
AKT activity by a dominant negative AKT construct or by a PI3K inhibitor
reduced active NF-kappaB and
STAT3 expression without significantly altering the activity of the latter
Fuglesteg et al., Basic Res Cardiol 2008
(Disease Models, Animal...) :
Inhibiting
STAT3 by AG490, or STAT3 depletion in cardiac myocytes
affects activation of
Akt , suggesting close interaction between STAT3 and Akt in the cardioprotective signalling pathway activated by insulin treatment at reperfusion
Quaglino et al., BMC cell biology 2009
:
In addition, we found that mammary cell stretching triggered involution associated cellular events as Leukemia Inhibitory Factor (LIF) expression induction,
STAT3 activation and
AKT phosphorylation
inhibition
Sakai et al., J Dent Res 2010
:
VEGF
induced ERK and
AKT phosphorylation ( indicative of differentiation ), while inhibiting phosphorylation of
STAT3 ( indicative of ` stemness ' )
Wang et al., PloS one 2010
(Reperfusion Injury) :
TLR4-deficiency was also associated with decreased phosphorylation of PI-3K and
AKT , but
increased activation of
STAT3
Bito et al., Journal of skin cancer 2011
:
These data suggest that
Stat3 activation through EGFR and/or
PI3K/Akt activation plays a critical role in the proliferation and survival of human cutaneous SCC
Dhingra et al., PloS one 2011
:
Akt regulates IL-10 mediated suppression of TNFa induced cardiomyocyte apoptosis by upregulating
Stat3 phosphorylation
Gu et al., Molecular cancer 2011
(Carcinoma, Hepatocellular...) :
IL-17 induces
AKT dependent
IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Liu et al., Toxicological sciences : an official journal of the Society of Toxicology 2012
:
JNK dependent
Stat3 phosphorylation
contributes to
Akt activation in response to arsenic exposure
Tu et al., J Cell Physiol 2013
(Arthritis, Rheumatoid...) :
Transfection of dominant negative
Akt or application of PI3K inhibitorLY294002 significantly
inhibited p-Tyr705-STAT3 , p-Ser727-STAT3, and PLGF expression, indicating that Akt is involved in JAK3/STAT3/PLGF signaling cascade
Bento et al., J Dent Res 2013
(MAP Kinase Signaling System) :
Exposure of SHED to EGM2-MV supplemented with VEGF
induced potent activation of ERK and
Akt signaling, while it inhibited phosphorylation of
STAT3
Sims et al., PloS one 2013
:
Imatinib reverses doxorubicin resistance by affecting activation of
STAT3 dependent NF-?B and
HSP27/p38/AKT pathways and by inhibiting ABCB1