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IRF6 — PHKA2

Text-mined interactions from Literome

Williams et al., J Immunol 2000 : Adhesion also stimulated tyrosine phosphorylation of Pyk2 and paxillin in monocytes, and this was further enhanced by LPS
Rosengart et al., Shock 2002 : Moreover, CD pretreatment abrogated adherence induced activation of Pyk2 , a major focal adhesion kinase, and ERK 1/2, a component of the mitogen activated protein kinase ( MAPK ) signaling pathway, and it completely inhibited LPS induced ERK 1/2 activation
Lin et al., Toxicol Appl Pharmacol 2008 : LPS stimulated Src, PYK2 , EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ), PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110
Anand et al., J Immunol 2008 : First, we observed a marked activation of Pyk2 in response to LPS ... Investigations into the molecular mechanism of this pathway revealed that LPS activates Pyk2 leading to IL-8 production through the TLR4
Anand et al., Mol Immunol 2009 (MAP Kinase Signaling System...) : Inhibition of Pyk2 activity using a pharmacological inhibitor, Tyrphostin A9 significantly attenuated LPS induced Pyk2 tyrosine phosphorylation, p38 MAP kinase ( MAPK ) activation, NF-kappaB activation, and MCP-1 expression