Gene interactions and pathways from curated databases and text-mining

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PCNA — SKP2

Text-mined interactions from Literome

Yeh et al., Biochem Biophys Res Commun 2001 : We report that SKP2 , an F-box protein and a substrate targeting component of the SCF ( SKP2 ) ubiquitin E3 ligase complex, mediates cyclin E degradation ... Our findings suggest that SKP2 regulates cyclin E stability, thus contributing to the control of S phase progression
Wang et al., Blood 2011 (Leukemia) : Mechanistically, we show that Skp2 deficiency induces Cyclin D1 gene expression, which contributes to an increase in HSC cycling