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CYP19A1 — LEP

Text-mined interactions from Literome

Magoffin et al., Ginekol Pol 1999 (Breast Neoplasms) : Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women ... The aromatase gene promoter in adipose stromal cells contains a functional STAT binding region, leading to the hypothesis that leptin may regulate aromatase activity in fat tissue
Catalano et al., J Biol Chem 2003 (Breast Neoplasms) : We have shown that leptin enhances aromatase mRNA expression, aromatase content, and its enzymatic activity in MCF-7 ... In the presence of either mitogen activated protein kinase inhibitor PD 98059 or ERK2 dominant negative as well as in the presence of STAT3 dominant negative, the stimulatory effects of leptin on aromatase promoter, enzymatic activity, and aromatase protein content were inhibited
Catalano et al., J Biol Chem 2004 (Disease Progression...) : We demonstrated that leptin induces aromatase activity in MCF-7 cells evidencing its important role in enhancing in situ estradiol production and promoting estrogen dependent breast cancer progression
Dunger et al., Best Pract Res Clin Endocrinol Metab 2005 (Insulin Resistance...) : Such circulating hormonal changes, together with elevated leptin levels and integral effects of fat cells on hormone action through local 11beta-steroid dehydrogenase and aromatase activity could effect rate of progression of pubertal development in obese subjects
Dundar et al., J Pediatr Endocrinol 2005 (Gynecomastia) : The role of circulating leptin in pubertal gynecomastia is probably related to increase in estrogen and/or estrogen/ androgen ratio by the stimulating effect of leptin on aromatase enzyme activity in both adipose and breast tissues, or a direct growth stimulating effect of leptin on mammary epithelial cells, or increase in sensitivity of breast epithelial cells to estrogen with inducing functional activation of estrogen receptors by leptin in breast tissue
Pino et al., J Endocrinol 2006 : Also, we studied the effect of leptin and 1,25 dihydroxyvitamin D3 ( 1,25 ( OH ) 2D3 ) on aromatase cell activity ... Both leptin and vitamin D increased aromatase activity during osteogenesis, but not during adipogenesis ; finally, we showed that favourable aromatase substrates concentration restrained MSCs adipogenesis but improved osteogenesis