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LEP — PTEN

Text-mined interactions from Literome

Ning et al., EMBO J 2006 : Potentially mediating this F-actin depolymerization, leptin , but not insulin, stimulated the phosphorylation of PTEN in a CK2 dependent manner, and inhibited its phosphatase activity ... These results demonstrate a critical role for PTEN in leptin signalling and indicate a mechanism by which leptin and insulin can produce PI3K dependent differential cellular outputs
Huypens et al., Med Hypotheses 2007 (Overweight) : The incretins GIP and GLP-1 increase IRS-2 levels in beta cells by acting via the cAMP-PKA pathway, whereas leptin inhibits PTEN activity via CK2 dependent pathways
Ning et al., J Biol Chem 2009 : Leptin dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels ... A previous study has established that leptin inhibits the activity of the phosphatase PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ), an important tumor suppressor and modifier of phosphoinositide signaling ... Inhibitors of the protein kinases CK2 and glycogen synthase kinase 3 ( GSK3 ) block leptin mediated PTEN phosphorylation
Moult et al., J Neurosci 2010 : In addition, leptin enhanced phosphorylation of the lipid phosphatase PTEN which inhibits PTEN function and elevates PtdIns ( 3,4,5 ) P ( 3 ) levels