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CTNNB1 — GAST
Text-mined interactions from Literome
Koh et al., J Clin Invest 2000
(Adenomatous Polyposis Coli...) :
Activation of
gastrin by
beta-catenin may therefore represent an early event in colorectal tumorigenesis and may contribute significantly toward neoplastic progression
Hollande et al., J Biol Chem 2001
:
Furthermore, glycine extended
gastrin ( 17 )
induced a PI3-kinase mediated tyrosine phosphorylation of the adherens junction protein
beta-catenin , partial dissociation of the complex between beta-catenin and the transmembrane protein E-cadherin, and delocalization of beta-catenin into the cytoplasm
Chakladar et al., Biochem Biophys Res Commun 2005
:
Synergistic
activation of the murine
gastrin promoter by oncogenic Ras and
beta-catenin involves SMAD recruitment
Cao et al., World J Gastroenterol 2006
(Colonic Neoplasms) :
To explore the
effect of
gastrin 17 (G17) on
beta-catenin/T cell factor-4 (Tcf-4) signaling in colonic cancer cell line Colo320WT ...
Gastrin17 activates
beta-catenin/Tcf-4 signaling in Colo320WT cells, thereby leading to over-expression of c-myc and cyclin D1
He et al., Biochim Biophys Acta 2008
:
A kinase-inactive mutant PAK1 ( K299A ) blocked the
gastrin stimulated dissociation of beta-catenin from E-cadherin, translocation of beta-catenin from the cell membrane to the nucleus, and association of
beta-catenin with the transcription factor TCF4