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EPS8 — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database ErbB1 downstream signaling: RAC1/GDP complex (RAC1) → SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) (modification, collaborate)
  Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database ErbB1 downstream signaling: SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) → RAC1/GTP complex (RAC1) (modification, activates) Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: RAC1/GDP complex (RAC1) → SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) (modification, collaborate)
  Scita et al., Nature 1999, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) → RAC1/GTP complex (RAC1) (modification, activates) Scita et al., Nature 1999, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) (modification, collaborate)
  Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004, Khanday et al., J Cell Biol 2006*
  Evidence: assay
• NCI Pathway Database Regulation of RAC1 activity: SOS1/Eps8/ABI1 complex (EPS8-ABI1-SOS1) → RAC1/GTP complex (RAC1) (modification, activates) Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Innocenti et al., J Cell Biol 2003, Sini et al., Nat Cell Biol 2004, Khanday et al., J Cell Biol 2006*
  Evidence: assay

Text-mined interactions from Literome

Chi et al., Biochem Biophys Res Commun 2004 : E3b1, a binding partner of Eps8, plays a critical role in receptor tyrosine kinase ( RTK ) -mediated Rac activation by facilitating the interaction of Eps8 with Sos-1 and the consequent activation of the Rac-specific guanine nucleotide exchange factor activity of Sos-1
Yap et al., Oncogene 2009 (Carcinoma, Squamous Cell...) : The latter cell functions may be modulated through the small GTP-ase, Rac1 and we used pull-down assays to investigate the role of Eps8 in Rac1 signaling
Hwang et al., J Cell Biol 2011 : Furthermore, CIIA promoted the formation of an SOS1-EPS8 complex and SOS1 mediated Rac1 activation , whereas it inhibited SOS1 mediated activation of Ras