◀ Back to PRKACB
ITPR1 — PRKACB
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
PRKACB
—
ITPR1
(interaction, mapped from kegg_pathways)
-
STRING interaction:
ITPR1
—
PRKACB
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Tang et al., J Neurosci 2003
(Calcium Signaling) :
We discovered that
PKA activates and PP1alpha inhibits the activity of recombinant
InsP3R1 reconstituted into planar lipid bilayers
Dyer et al., Biochem Biophys Res Commun 2003
(Ion Channel Gating) :
The
effects of
PKA on the
type I InsP(3) receptor using single channel electrophysiological studies were also investigated
Hur et al., J Cell Biol 2005
(Calcium Signaling) :
The IP ( 3 ) R complex functions as a focal point to promote Ca ( 2+ ) release in two ways : ( 1 ) it facilitates
PKA dependent phosphorylation of
IP(3)R1 in response to BK-induced elevation of cAMP, and ( 2 ) it couples the plasmalemmal EGFR with IP(3)R1 at the Ca ( 2+ ) store located juxtaposed to the plasma membrane
Soulsby et al., Cell Calcium 2007
:
Several studies have shown that
PKA mediated phosphorylation of
IP3R1 at serines S1588 and S1755 enhances the receptor 's ability to mobilize Ca2+
Matsumoto et al., Cell Res 2012
(Calcium Signaling) :
A recent report in Nature showed that
PKA dependent phosphorylation of the
inositol-1,4,5-trisphosphate receptor ( InsP3R ) induces Ca mobilization, leading to increase in the phosphatase activity of calcineurin and the subsequent dephosphorylation of CRTC2, thereby resulting in the induction of gluconeogenic gene expression