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ABL1 — GRB2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(direct interaction, pull down)
Ren et al., Genes Dev 1994*
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(physical association, affinity chromatography technology)
Patel et al., Genes Chromosomes Cancer 2006*
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(physical association, affinity chromatography technology)
Johnson et al., PloS one 2009*
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(direct interaction, pull down)
Gaston et al., Exp Hematol 2004*
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(direct interaction, two hybrid)
Gaston et al., Exp Hematol 2004*
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(physical association, affinity chromatography technology)
Chen et al., Blood 2013*
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(physical association, affinity chromatography technology)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(physical association, affinity chromatography technology)
Warmuth et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
GRB2
—
ABL1
(direct interaction, two hybrid)
Ren et al., Genes Dev 1994*
-
IRef Hprd Interaction:
Complex of ABL1-GRB2-CBL-GRB2-CBL-CBL-ABL1-GRB2-ABL1
(in vivo)
Gaston et al., Exp Hematol 2004*
-
IRef Hprd Interaction:
ABL1
—
GRB2
(two hybrid)
Gaston et al., Exp Hematol 2004*, Ren et al., Genes Dev 1994*, Romero et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
ABL1
—
GRB2
(in vitro)
Gaston et al., Exp Hematol 2004*, Ren et al., Genes Dev 1994*, Romero et al., J Biol Chem 1998*
-
IRef Innatedb Interaction:
GRB2
—
ABL1
(unknown, -)
Feng et al., J Biol Chem 1996
-
IRef Intact Interaction:
GRB2
—
ABL1
(physical association, peptide array)
Wu et al., Proteomics 2007
-
IRef Ophid Interaction:
GRB2
—
ABL1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Jahn et al., J Biol Chem 2001
:
We demonstrate that the inhibitory activity of
Grb4 is
independent of the direct interaction of
v-Abl and Grb4 : a Grb4 mutant that lacks a functional SH2 domain shows an even more pronounced inhibition of AP-1/SRE
Gaston et al., Exp Hematol 2004
:
In a yeast three-hybrid assay,
Grb2 mediated an interaction between Cbl and
Bcr-Abl that was dependent on a functional Grb2 binding site ...
Grb2 or another, yet unidentified, protein may
mediate an initial interaction between Cbl and
Bcr-Abl that is independent of Cbl tyrosine phosphorylation
Modi et al., Leukemia 2011
(Cell Transformation, Neoplastic...) :
The adapter protein growth factor receptor binding protein-2 ( Grb2 ) can bind phosphorylated
BCR/ABL-Y177 ,
induce Grb2-SoS complex formation and activate Ras signaling
Tanaka et al., Mol Cell Biol 1995
:
Activation of Erk-1 by oncogenic
Abl was effectively
inhibited by
Grb2 with mutations in either its SH2 or SH3 domain or by Crk-1 with an SH3 domain mutation ... These results suggest that both Crk and
Grb2 may
contribute to the activation of Erk by oncogenic
Abl , whereas Nck is unlikely to participate in this pathway