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Text-mined interactions from Literome
Kaburagi et al., Diabetologia 2001
:
Insulin independent and wortmannin-resistant targeting of
IRS-3 to the plasma membrane via its pleckstrin homology domain
mediates a different interaction with the
insulin receptor from that of IRS-1
Hemi et al., J Biol Chem 2002
(Insulin Resistance...) :
Similar to TNF, cycloheximide and anisomycin stimulated serine phosphorylation of IRS-1 and IRS-2, reduced their ability to interact with the
insulin receptor ,
inhibited the insulin induced tyrosine phosphorylation of
IRS proteins, and diminished their association with phosphatidylinositol 3-kinase (PI3K)