◀ Back to FOS
DEFB4B — FOS
Text-mined interactions from Literome
Tomita et al., Respirology 2002
:
Lipopolysaccharide induced gene expression of
hBD-2 was
down-regulated by ( i ) dexamethasone, ( ii ) inhibition of NF-kappaB and
AP-1 , and ( iii ) intracellular calcium chelator ... These findings suggest that glucocorticoids ( GC ), but not COX inhibitors, reduce hBD-2 gene expression, while NF-kappaB,
AP-1 and intracellular calcium are
essential for
hBD-2 expression
Wehkamp et al., Infect Immun 2004
:
NF-kappaB- and
AP-1 mediated
induction of human
beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917 : a novel effect of a probiotic bacterium ... Luciferase gene reporter analyses and site directed mutagenesis experiments demonstrated that functional binding sites for NF-kappaB and
AP-1 in the hBD-2 promoter are
required for induction of
hBD-2 through E. coli Nissle 1917
Voss et al., J Biol Chem 2006
(Crohn Disease) :
Luciferase gene reporter analyses and site directed mutagenesis experiments demonstrated that functional binding sites for NF-kappaB and
AP-1 in the hBD-2 promoter are
required for NOD2 mediated induction of
hBD-2 through MDP
Wehkamp et al., J Invest Dermatol 2006
:
Pseudomonas aeruginosa- and IL-1beta mediated induction of human
beta-defensin-2 in keratinocytes is
controlled by NF-kappaB and
AP-1
Kanda et al., Am J Physiol Cell Physiol 2007
:
These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma induced
hBD-2 production
dependent on NF-kappaB,
AP-1 , or STAT1 in human keratinocytes
Yoon et al., Infect Immun 2010
:
In contrast, suppression of
AP-1 did not
affect hBD-2 expression in BFT stimulated cells