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CDKN1A — CHEK2

Text-mined interactions from Literome

Zhang et al., J Nutr 2006 (Pancreatic Neoplasms) : BITC mediated G2/M arrest was associated with up-regulation of cyclin dependent kinase inhibitor p21 ( Waf1/Cip1 ) and the activation of checkpoint kinase 2 , whereas the expressions of other G2/M regulatory proteins, including CyclinB1, Cdc2, and cell division cycle 25C (Cdc25C), were down-regulated by 19, 51, and 70 %, respectively, compared with control
Spurlock et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : In tissue culture, MTX induced expression of both p53 and p21 by JNK-2- and JNK-1 dependent mechanisms, respectively, while CHEK2 and RANGAP1 were not induced by MTX
Mackenzie Ross et al., Pigment Cell Melanoma Res 2013 (Disease Progression...) : Two separate defects in p53 signaling appeared common : in nevi, lack of p53 phosphorylation by activated CHEK2 , and in melanomas, defective p21 upregulation by p53 even when phosphorylated