Gustafson et al., Oncogene 2010
:
Phosphorylation of Myc proteins is controlled in-part by the receptor tyrosine kinase/phosphatidylinositol 3-kinase/Akt/mTOR signaling , with additional contributions from Aurora A kinase
Tan et al., Cancer Cell 2010
(Cell Transformation, Neoplastic...) :
On loss of PPP2R2B, mTORC1 inhibitor rapamycin triggers a compensatory Myc phosphorylation in PDK1 dependent, but PI3K and AKT independent manner, resulting in resistance
Babcock et al., J Biol Chem 2013
:
These findings indicate that the induction of ATF4/CHOP expression occurs via mTORC1 regulation of c-MYC and that this signaling pathway is a major determinant in the ability of bortezomib to induce apoptosis