Gene interactions and pathways from curated databases and text-mining

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HMGB1 — TNFSF11

Text-mined interactions from Literome

Bidwell et al., J Cell Biochem 2008 (Bone Resorption) : Extracellular HMGB1 enhances the expression of RANKL , TNFalpha, and IL6 in osteoblastogenic bone marrow stromal cell cultures, and it is chemotactic to osteoclasts
Zhou et al., J Bone Miner Res 2008 : HMGB1 is released from macrophages in response to RANKL stimulation and is required for RANKL induced osteoclastogenesis in vitro and in vivo
Kim et al., J Cell Biochem 2010 (Bone Resorption) : Inhibition of SIRT1 by sirtinol or SIRT1 siRNA blocked the HMGB1 stimulated expression of RANKL and cytokines