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CEBPA — IL1B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CEBPA → IL1B (decreases, IL1B Activity) Blais et al., DNA Cell Biol 2005*
  Evidence: Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter,
• OpenBEL Selventa BEL large corpus: CEBPA → IL1B (increases, IL1B Activity) Nie et al., Mol Cell Biol 2003*
  Evidence: In our cell system, treatment with IL-1 (1 ng/ml for 1 h) induced the nuclear protein-DNA complexes (Fig. 5D, lane 2) with the COX-2 NF–IL-6 probe compared to the control (lane 1), which were abolished by C/EBP antibody accompanied by a retarded band (lane 4). In contrast, C/EBP antibody did not alter the complexes (lane 3), demonstrating that IL-1 induces C/EBP binding to the COX-2 NF–IL-6 element.

Text-mined interactions from Literome

Afink et al., Biochem Biophys Res Commun 2004 (Sarcoma) : In addition, forced expression of C/EBPbeta could mimic the IL-1beta effect on the promoter activity, but subsequent mutation analysis of the C/EBP binding sites indicated that direct C/EBP binding to the promoter is not required for the IL-1beta response
Giltiay et al., J Lipid Res 2005 (Inflammation) : In this study, we investigate the role of ceramide in the IL-1beta regulation of C/EBP in primary hepatocytes
Lagathu et al., Diabetologia 2006 (Inflammation...) : Down-regulation of peroxisome proliferating activated receptor gamma and CCAAT/enhancer binding protein alpha in response to IL1B may have contributed to the altered phenotype of IL1B treated adipocytes
Maranto et al., J Neuroimmune Pharmacol 2008 : Inhibition of IL-1beta mediated C3 promoter activation by the dominant negative mutant of p38-alpha mitogen activated protein kinase suggests that IL-1beta induces C3 expression through the activation of C/EBP
Liang et al., Mol Hum Reprod 2008 : Since IL-1beta activates NFkappaB, AP-1 and C/EBP , we over expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression
Hecker et al., Br J Pharmacol 1997 : Moreover, staurosporine significantly augmented the activation of C/EBP by IL-1 beta and forskolin