Gene interactions and pathways from curated databases and text-mining

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CTR9 — IL1B

Text-mined interactions from Literome

Alvi et al., Immunology 1999 : We conclude that CRH and PAF can induce the expression of IL-1beta , but this is not obligatory for increased PGE2 release, and the effect of these stimuli on COX-2 expression is a direct, IL-1beta independent effect
Warren et al., Am J Pathol 1992 (Acute Disease...) : Stimulation of isolated mouse alveolar macrophages with recombinant murine IL-1 beta or IL-1 alpha resulted in rapid, dose dependent, and cell concentration dependent increases in PAF secretion
Fernandes et al., Br J Pharmacol 2005 (Edema) : TNF-alpha was necessary for the local PAF induced IL-1beta production
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006 (Disease Models, Animal...) : H ( 2 ) O ( 2 ) causes formation of IL-1beta that may induce production of PAF in the muscle, possibly closing a self sustaining cycle of production of inflammatory mediators
Cheng et al., J Pharmacol Exp Ther 2006 (Esophagitis) : In circular muscle, exogenous PAF induced sequential formation of IL-6, H ( 2 ) O ( 2 ), IL-1beta , and PAF
Sneddon et al., Biochim Biophys Acta 2006 : Both TNF-alpha and IL-1beta induced HUVEC platelet activating factor (PAF) production and PAF was required for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine )
Barthelson et al., Lipids 1991 : PAF , alone and in combination with endotoxin, caused an increase in mRNA levels for IL-1 beta ... The magnitude of the effects of PAF on IL-1 beta mRNA levels matched closely the effects seen at the level of protein synthesis, suggesting that the effects of PAF on IL-1 beta release may result largely from its effects on IL-1 beta mRNA levels
Kunze et al., Prostaglandins Other Lipid Mediat 2010 (Inflammation) : An immediate low release of PGE ( 2 ) was induced by PAF, phorbol ester and arachidonic acid but not by IL1beta , TNF-alpha and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta, TNF-alpha and LPS but not by PAF , phorbol ester and arachidonic acid
Barthelson et al., Cell Immunol 1990 : To assess the effect of PAF on IL-1 beta synthesis, THP-1 cell pellet proteins were separated by SDS-PAGE, blotted, and immunostained to detect IL-1 beta ... Immunostaining revealed that PAF increases intracellular IL-1 beta precursor and that the combination of PAF and LPS increases IL-1 beta precursor synergistically ... PAF increases IL-1 beta release mainly by increasing IL-1 beta synthesis
Gutierrez et al., Clin Exp Immunol 1995 : IL-1 beta and IL-6 stimulate the production of platelet activating factor (PAF) by cultured rabbit synovial cells
Takata et al., Am J Pathol 1994 : Interleukin-1 beta and tumor necrosis factor-alpha induce PAF production by endothelium, and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist
Yoshikawa et al., Biofactors 1998 : PAF induced upregulation of CD11b and CD18 on neutrophils and IL-1 beta increased surface expression of ICAM-1 and VCAM-1 on HUVEC