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CTR9 — IL1B
Text-mined interactions from Literome
Alvi et al., Immunology 1999
:
We conclude that CRH and
PAF can
induce the expression of
IL-1beta , but this is not obligatory for increased PGE2 release, and the effect of these stimuli on COX-2 expression is a direct, IL-1beta independent effect
Warren et al., Am J Pathol 1992
(Acute Disease...) :
Stimulation of isolated mouse alveolar macrophages with recombinant murine
IL-1 beta or IL-1 alpha
resulted in rapid, dose dependent, and cell concentration dependent increases in
PAF secretion
Fernandes et al., Br J Pharmacol 2005
(Edema) :
TNF-alpha was necessary for the local
PAF induced
IL-1beta production
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006
(Disease Models, Animal...) :
H ( 2 ) O ( 2 ) causes formation of
IL-1beta that may
induce production of
PAF in the muscle, possibly closing a self sustaining cycle of production of inflammatory mediators
Cheng et al., J Pharmacol Exp Ther 2006
(Esophagitis) :
In circular muscle, exogenous
PAF induced sequential formation of IL-6, H ( 2 ) O ( 2 ),
IL-1beta , and PAF
Sneddon et al., Biochim Biophys Acta 2006
:
Both TNF-alpha and
IL-1beta induced HUVEC platelet activating factor (PAF) production and
PAF was
required for subsequent firm THP-1 monocyte adhesion since it was inhibited by both PAF receptor antagonists ( BN-52021 or CV-6209 ) and a PAF synthesis inhibitor ( sanguinarine )
Barthelson et al., Lipids 1991
:
PAF , alone and in combination with endotoxin,
caused an increase in mRNA levels for
IL-1 beta ... The magnitude of the
effects of
PAF on
IL-1 beta mRNA levels matched closely the effects seen at the level of protein synthesis, suggesting that the effects of PAF on IL-1 beta release may result largely from its effects on IL-1 beta mRNA levels
Kunze et al., Prostaglandins Other Lipid Mediat 2010
(Inflammation) :
An immediate low release of PGE ( 2 ) was
induced by PAF, phorbol ester and arachidonic acid but not by
IL1beta , TNF-alpha and LPS whereas a delayed high release of PGE ( 2 ) was induced by the inflammatory agents IL1beta, TNF-alpha and LPS but not by
PAF , phorbol ester and arachidonic acid
Barthelson et al., Cell Immunol 1990
:
To assess the
effect of
PAF on
IL-1 beta synthesis, THP-1 cell pellet proteins were separated by SDS-PAGE, blotted, and immunostained to detect IL-1 beta ... Immunostaining revealed that
PAF increases intracellular
IL-1 beta precursor and that the combination of PAF and LPS increases IL-1 beta precursor synergistically ...
PAF increases
IL-1 beta release mainly by increasing IL-1 beta synthesis
Gutierrez et al., Clin Exp Immunol 1995
:
IL-1 beta and IL-6
stimulate the production of
platelet activating factor (PAF) by cultured rabbit synovial cells
Takata et al., Am J Pathol 1994
:
Interleukin-1 beta and tumor necrosis factor-alpha
induce PAF production by endothelium, and PMN migration across cytokine activated endothelium was inhibited by a PAF receptor antagonist
Yoshikawa et al., Biofactors 1998
:
PAF induced upregulation of CD11b and CD18 on neutrophils and
IL-1 beta increased surface expression of ICAM-1 and VCAM-1 on HUVEC