Gene interactions and pathways from curated databases and text-mining

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IL1B — IL21

Text-mined interactions from Literome

Lottaz et al., J Invest Dermatol 2001 : In interleukin-1beta transfected human dermal fibroblasts, interleukin-8 was induced through an autocrine activity of interleukin-1beta
Hassanain et al., Neuroscience 2003 : In particular, interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of interleukin-1beta on this form of emotional behavior are mediated via a 5-HT2 receptor mechanism
Fujiwara et al., Cancer Res 1992 : Specific inhibition of interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory role of interleukin 1 in the generation of lymphokine activated killer cells
Luz et al., Neuropeptides 2006 (Dehydration...) : These results suggest that the central activation of interleukin-1 receptors by IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Bernardino et al., J Neurochem 2008 (Encephalitis...) : Potentiation of AMPA toxicity was prevented when IL-1beta production or its receptor signaling were blocked by an inhibitor of interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Kattah et al., Arthritis Rheum 2008 : IL-1beta and IL-6 independently induced IL-21 secretion, but the presence of IL-21 alone was not sufficient for IL-17 production
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Sutton et al., Immunity 2009 (Encephalomyelitis, Autoimmune, Experimental) : Here, we show that gammadelta T cells express IL-23R and the transcription factor RORgammat and produce IL-17, IL-21 , and IL-22 in response to IL-1beta and IL-23, without T cell receptor engagement
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Rodriguez-Cimadevilla et al., Blood 1990 (Leukemia, Myeloid, Acute) : Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia : role of interleukin-1 as an endogenous inducer
Mauviel et al., Biochem Biophys Res Commun 1988 : The ability of the two forms of interleukin-1 , IL-1 alpha and IL-1 beta, to induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Yoza et al., J Biol Chem 1996 : In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene
Kang et al., Spine (Phila Pa 1976) 1997 (Intervertebral Disc Displacement) : Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta
Kiriyama et al., J Neuroimmunol 1997 (Glioblastoma) : In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP