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CD79A — HNRNPH1
Text-mined interactions from Literome
Sato et al., J Immunol 2003
:
Compared with SP DCs, freshly isolated PP
DCs induced higher levels of
IgA secretion from naive B cells in DC-T cell-B cell coculture system in vitro ... The
IgA production
induced by PP
DCs was attenuated by neutralization of IL-6 ... In addition, the
induction of
IgA secretion by SP DCs, but not PP
DCs , was further enhanced by the addition of exogenous IL-6 ... These results suggest a unique
role of PP CD11b ( + )
DCs in enhancing
IgA production from B cells via secretion of IL-6
Macpherson et al., Science 2004
:
This allows
DCs to selectively
induce IgA , which helps protect against mucosal penetration by commensals
Sato et al., Cell Mol Life Sci 2005
:
Here we discuss recent studies that describe the role of PP DCs in immune induction and speculate on the mechanism by which the resident
DCs regulate T cell and
immunoglobulin A (IgA) responses in the gastrointestinal mucosa
Konrad et al., Gastroenterology 2006
(Disease Models, Animal) :
Antigen pulsed
dendritic cells (DCs) stimulated production of specific
IgA in the absence of T-cell help via costimulation by BAFF and/or APRIL, members of the TNF family
Manicassamy et al., Semin Immunol 2009
:
In addition, RA programs
DCs to imprint mucosal homing properties on activated T and B cells, and
enhanced induction of
immunoglobulin-A (IgA) by B cells
Tezuka et al., Immunol Rev 2010
(Inflammatory Bowel Diseases) :
This review outlines the roles of the commensal flora, epithelial layer, and GALT in mucosal homeostasis and inflammatory conditions and highlights recent progress in our understanding of how
DCs are
involved in
IgA synthesis in the gut
McDonald et al., Am J Pathol 2012
:
Moreover, CD103 ( + )
DCs preferentially associated with the small intestine epithelium and LP CD103 ( + ) DC ALDH activity, and the ability to promote
IgA production was
reduced in mice with impaired DC-epithelia associations
Pinchuk et al., J Immunol 1996
(Burkitt Lymphoma) :
Furthermore, CD40L on DCs was functional, since CD40L+
DCs , unlike CD40L- DCs,
induced B cell IgG and
IgA production, and this induction could be inhibited by blocking CD40L-CD40 interactions with mAb to CD40L