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GLO1 — TNF
Text-mined interactions from Literome
Van Herreweghe et al., Proc Natl Acad Sci U S A 2002
:
Tumor necrosis factor induced modulation of
glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal derived AGE ... Furthermore, we provide evidence that the
TNF induced phosphorylation of
glyoxalase I is not involved in detoxification of MG by means of the glyoxalase system, but that phosphorylated glyoxalase I is on the pathway leading to the formation of a specific MG-derived advanced glycation end product
de Hemptinne et al., Biochem J 2007
:
We have previously shown that
TNF ( tumour necrosis factor )
induces phosphorylation of
GLO1 ( glyoxalase I ), which is required for cell death in L929 cells ... In the present paper, we show that the
TNF induced phosphorylation of
GLO1 occurs primarily on the NO ( nitric oxide ) -responsive form of GLO1 ... In summary, these data suggest that the
TNF induced phosphorylation of
GLO1 is the dominant factor for cell death
de Hemptinne et al., Mol Cell Biochem 2009
:
By using this phospho-specific antibody, we demonstrated that
TNF induces phosphorylation of
GLO1 on Thr-106