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MCOLN1 — PTH
Text-mined interactions from Literome
De Rouffignac et al., Am J Physiol 1991
:
In the mouse, antidiuretic hormone ( ADH ),
parathyroid hormone , glucagon, calcitonin, and isoproterenol
stimulate Na+, Cl-,
Mg2+ , and Ca2+ transports in the cortical TAL, whereas ADH, glucagon, and isoproterenol stimulate NaCl transport only in the medullary TAL
Nagy et al., Endocrinology 1990
(Insulin Resistance) :
The receptor antibody did not affect
PTH stimulated ( Ca2+ +
Mg2+ ) ATPase activity, nor did it affect other kidney basolateral membrane ATPase basal activities
Itoh et al., Biochem Biophys Res Commun 1988
:
From these results, it is proposed that
PTH stimulates (
Ca2++Mg2+ ) -ATPase activity by enhancing its affinity for free Ca2+ via cAMP dependent phosphorylation of a BLM protein of Mr 9000
Mahaffee et al., Endocrinology 1982
:
We have correlated the
effects of
Mg2+ and Ca2+ on
parathyroid hormone (PTH) secretion and cAMP accumulation by rat parathyroid tissues in vitro with the effects of these two metals on adenylate cyclase activity in broken membrane preparations ...
Mg2+ may
promote PTH secretion either by enhancing the activation of adenylate cyclase by endogenous guanine nucleotides or by competing with Ca2+ for binding to a distinct regulatory site on the enzyme
Shoback et al., Mol Cell Endocrinol 1984
:
In contrast, in cells exposed to subphysiological extracellular Ca2+ concentrations ( less than or equal to 10 ( -6 ) M ), 5 mM
Mg2+ had little or no effect on either cytosolic Ca2+ or
PTH release
Wittner et al., Pflugers Arch 1993
:
In the presence of luminal furosemide and a chemically imposed lumen-to-bath directed NaCl gradient, which generates a lumen negative PDte,
PTH slightly but significantly
increased Ca2+ and
Mg2+ net secretion
Miki et al., Am J Physiol 1997
:
To study mechanisms responsible for regulation of PTH release by cations, we investigated the
effect of
Mg2+ on cytosolic Ca2+ levels ( [ Ca2+ ] i ) and
PTH secretion in single isolated bovine parathyroid cells