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MAP2K1 — MMP2

Text-mined interactions from Literome

Kurata et al., Exp Cell Res 2000 : Constitutive activation of MAP kinase kinase ( MEK1 ) is critical and sufficient for the activation of MMP-2 ... We investigated the role of MEK1 signaling in MMP-2 activation by use of constitutive active/dominant negative forms of MEK1 and MEK1-specific inhibitor ... Contrary, expression of dominant negative form of MEK1 in v-src transformed cells or in Con A-activated cells resulted in the suppression of the augmented secretion and proteolytic activation of MMP-2
Pan et al., J Biol Chem 2002 : Third, overexpression of constitutively active MEK1 stimulates Sp1 phosphorylation and MMP-2 promoter activity and antagonizes the inhibition of NSAIDs
Atkinson et al., FEBS Lett 2004 (Fibrosarcoma...) : Cellular cholesterol regulates MT1 MMP dependent activation of MMP 2 via MEK-1 in HT1080 fibrosarcoma cells ... A specific inhibitor of mitogen activated protein kinase kinase 1/2 inhibited both MMP 2 activation and extracellular signal related kinase phosphorylation induced by cholesterol depletion
Miyata et al., Mol Cancer Ther 2004 (Neoplasm Invasiveness) : Therefore, these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms : ( 1 ) the inhibition of MEK1/2 activity is involved in the suppression of MMP expression and ( 2 ) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression
Xu et al., Cancer Lett 2007 (Carcinoma, Hepatocellular...) : MEK1/2 inhibitor, U0126, inhibited MMP-2 , FAK and actin expression in FHCC-98 cell line
Gong et al., Mol Cancer Ther 2008 (Neoplasm Invasiveness...) : Inhibitor of MMPs significantly blocked p37 induced EGFR but has little effect on extracellular signal regulated kinase phosphorylation, whereas the p37 induced MMP-2 activation was only partially suppressed by inhibitor of MEK1/2 or by inhibitor of EGFR
Liu et al., J Cell Physiol 2010 : Transfection of constitutively active MEK1 or pretreatment with SB202190 ( p38 MAPK inhibitor ) restored MMP-2 and MMP-9 protein expression in caffeine treated cells
Huang et al., J Cell Physiol 2012 (Breast Neoplasms...) : Moreover, suppression of MEK1 , by dominant negative, kinase-dead MEK1 cDNA construct or MEK1-specific small interfering RNA ( siRNA ) as well as MEK1 inhibitors, blocked MED28 induced MMP2 activation, cellular migration, and invasion in breast cancer cells
Liu et al., Int J Biochem Cell Biol 2012 (Calcium Signaling) : Transfection of constitutively active MEK1 restored MMP-2 and MMP-9 promoter activity in CIL-102 treated cells, while suppression of p38 MAPK/JNK activation abolished CIL-102 induced MMP-2/MMP-9 mRNA decay