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CRK — MAPKAPK2

Text-mined interactions from Literome

Lasa et al., Mol Cell Biol 2000 (MAP Kinase Signaling System) : This stabilization was blocked by SB203580, an inhibitor of p38 , and by two different dominant negative forms of MAPK activated protein kinase 2 ( MAPKAPK-2 ), a kinase lying downstream of p38
Verma et al., J Biol Chem 2002 : Such type I IFN-inducible phosphorylation of p38 results in activation of the catalytic domain of the kinase and sequential activation of the MAPK activated protein kinase-2 ( MapKapK-2 kinase ), indicating the existence of a signaling cascade, activated downstream of p38 in hematopoietic progenitors
Underwood et al., Structure 2003 : However, phosphorylation of MK2 41-364 by p38 restores the V ( max ) and K ( m ) for peptide substrate to values comparable to those seen in p38 activated MK2 41-400, suggesting a mechanism for regulation of enzyme activity
Anur et al., Blood 2012 (Disease Models, Animal...) : Low doses ( 50nM ) of both agents inhibited p38 MAPK dependent activation of MAPKAPK2 (MK2) and suppressed MK2 dependent TNFa production without substantially influencing TNFa gene transcription
Beyaert et al., EMBO J 1996 : TNF Treatment of cell activated the p38 MAP kinase pathway, as revealed by increased phosphorylation of p38 MAP kinase itself, activation of the substrate protein MAPKAP kinase-2 , and culminating in the phosphorylation of the heat shock protein 27 (hsp27)
Sanghera et al., J Immunol 1996 : Consistent with p38 HOG1 mediating LPS activation of MAPKAPK2 , treatment with LPS, but not PMA, increased the tyrosine phosphorylation of p38 HOG1, a modification known to elevate the enzymatic capacity of this kinase
Schäfer et al., J Biol Chem 1998 : Using the specific inhibitor of p38 MAP kinase, SB 203580, we found that p38 MAP kinase activity was required for MAP kinase activated protein kinase-2 activation in pancreatic acini