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LPA — PKD3

Text-mined interactions from Literome

Chiu et al., Am J Physiol Cell Physiol 2001 : PKD in intestinal epithelial cells : rapid activation by phorbol esters, LPA , and angiotensin through PKC ... PKD was also rapidly activated in these cells by lysophosphatidic acid (LPA) or angiotensin in a concentration dependent fashion via a PKC dependent pathway ... LPA induced PKD activation was prevented selectively by treatment with pertussis toxin
Rodriguez Perez et al., Am J Physiol Gastrointest Liver Physiol 2011 : LPA induced PKD activation was also inhibited by Ki16425, pertussis toxin, GF109203X, and Go6983
Lynch et al., J Recept Signal Transduct Res 2013 : Lysophosphatidic acid (LPA) is a GPCR agonist that has previously been shown to activate protein kinase D (PKD) in non-muscle cells ; however, whether PKD is activated in response to LPA in skeletal muscle myoblasts, and the identities of signaling intermediates that regulate this activation, have not been defined ... Objective : To determine whether PKD is activated in response to LPA administration in myoblasts, and to define the signaling pathways that mediate LPA stimulated PKD phosphorylation ... Pharmacological inhibition and RNA-interference were used to target specific molecules to determine their involvement in LPA induced PKD phosphorylation ... Loss of PKCd, but not the loss of PKCa, prevented LPA induced PKD phosphorylation