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EGR1 — LDLR

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2003 (Carcinoma, Hepatocellular...) : Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene ... Because the SIRE motif is composed of a c/EBP binding site and a cAMP response element, both of which are quite divergent from the classical GC-rich Egr1 recognition sequences, we hypothesized that Egr1 may regulate LDLR transcription through interacting with members of the c/EBP and CREB families ... Taken together, we provide strong evidence that Egr1 regulates LDLR transcription via a novel mechanism of protein-protein interaction with c/EBPbeta
Zhou et al., Biochem J 2006 (Carcinoma, Hepatocellular...) : Our previous studies [ Zhang, Ahlborn, Li, Kraemer and Liu ( 2002 ) J. Lipid Res. 43, 1477-1485 ; Zhang, Lin, Abidi, Thiel and Liu ( 2003 ) J. Biol. Chem. 278, 44246-44254 ] have demonstrated that OM transiently induces EGR-1 ( early growth response gene product 1 ) expression and EGR-1 activates LDLR transcription primarily through a protein-protein interaction with C/EBPbeta, which serves as a co-activator of EGR-1
Liu et al., Cell Growth Differ 1993 (Carcinoma, Hepatocellular...) : The correlation among tyrosine kinase phosphorylation, Egr-1 induction , and LDL receptor regulation suggests that Egr-1 may be a nuclear signal transducer utilized by OM to induce transcription of the LDL receptor gene