◀ Back to GFAP

ADCYAP1 — GFAP

Text-mined interactions from Literome

Cebolla et al., J Neurosci 2008 (Calcium Signaling) : Cortical progenitor cells from dream ( -/- ) mice fail to express GFAP in response to PACAP
Lastres-Becker et al., Mol Cell Neurosci 2008 : However, inhibition of protein kinase A does not prevent PACAP induced GFAP gene expression or astrocytogenesis ... PACAP also activates the small GTPases Rap1 and Ras, but either activation of Rap1 alone by selective stimulation of the guanine nucleotide exchange factor Epac, or expression of a constitutively active form of Ras, do not induce GFAP gene expression ... Ras is activated by PACAP in a cAMP dependent manner, and inhibition of Ras and/or Rap1 decreases PACAP induced GFAP promoter stimulation ... Thus, cAMP dependent PACAP induced GFAP expression during astrocytogenesis involves the coordinated activation of both Ras and Rap1, but activation of either one of them in isolation is not sufficient to trigger this response