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CD40 — IL13
Text-mined interactions from Literome
Bartholomé et al., J Interferon Cytokine Res 1999
:
IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells : selective inhibition of
CD40 dependent
interleukin-12 secretion
Kitagawa et al., Arthritis Rheum 1999
(Arthritis, Rheumatoid) :
Differential
regulation of rheumatoid synovial cell
interleukin-12 production by tumor necrosis factor alpha and
CD40 signals
Muraille et al., Blood 1999
:
Anti-CD3epsilon treatment was found to induce a selective deficiency in the ability of spleen cells to produce bioactive
interleukin-12 in
response to
CD40 stimulation
Haas et al., Immunology 2000
:
Analysis of cytokine receptor mRNA indicates that activation through
CD40 , in the presence or absence of IgM cross linking,
results in increased IL-4 receptor-alpha ( IL-4Ralpha ),
IL-13Ralpha1 and interferon-alpha receptor 1 ( IFN-alphaR1 ) mRNA levels
Reider et al., J Allergy Clin Immunol 2002
(Hypersensitivity) :
Production of IL-4, IL-5, IL-10, IL-12, and
IL-13 in
response to
CD40 ligation was measured with ELISA
Cattaruzza et al., J Biol Chem 2003
:
Interleukin-10 induction of nitric-oxide synthase expression attenuates
CD40 mediated
interleukin-12 synthesis in human endothelial cells
Kaufman et al., J Immunol 2004
(Pulmonary Fibrosis) :
Interestingly,
CD40L expression is down-regulated by IFN-gamma, a type 1 cytokine with antiscarring properties, and is
up-regulated by the profibrogenic type 2 cytokine
IL-13
Hajoui et al., J Allergy Clin Immunol 2004
(Hypersensitivity, Immediate) :
The synthesis of
IL-13 required both
CD40 and IL-4 stimulation
Pinzon-Charry et al., Neoplasia (New York, N.Y.) 2005
(Adenocarcinoma...) :
Importantly, despite DR ( + ) IC 's poor responsiveness to inflammatory factors, in samples from healthy volunteers and breast cancer patients,
CD40 ligation
induced phenotypic maturation and
interleukin 12 secretion, in turn generating more efficient T-cell responses
Zhou et al., J Immunol 2007
:
Iloprost and cicaprost also suppressed LPS induced expression of CD86,
CD40 , and MHC class II molecules by BMDCs and
inhibited the ability of BMDCs to stimulate Ag-specific CD4 T cell proliferation and production of IL-5 and
IL-13
Danese et al., Gut 2007
(Colitis...) :
Engagement of
CD40 on HIFs
promoted the release of vascular endothelial growth factor ( VEGF ),
interleukin-8 (IL-8) and hepatocyte growth factor (HGF)
Bose et al., Hum Immunol 2007
(Carcinoma, Squamous Cell...) :
Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with
CD40-CD40L mediated endogenous production of
interleukin-12
Saw et al., Am J Pathol 2009
(Pemphigoid, Benign Mucous Membrane) :
IL-13 also
up-regulated surface expression of HLA-DR, CD80,
CD40 , and CD154 by conjunctival fibroblasts, suggesting a potential mechanism for fibroblast-T cell cross talk, via which fibroblasts may actively engage in perpetuating chronic inflammation and continued fibrosis
Punnonen et al., J Immunol 1994
:
However, in contrast to IL-4,
IL-13 did not
enhance CD23,
CD40 , and HLA-DR expression on cultured s mu- pre-B cells in the absence of other stimuli, suggesting that IL-13 alone does not activate pre-B cells
Kennedy et al., Eur J Immunol 1996
:
CD40/CD40 ligand interactions are
required for T cell dependent production of
interleukin-12 by mouse macrophages
Cella et al., J Exp Med 1996
:
Ligation of
CD40 on dendritic cells
triggers production of high levels of
interleukin-12 and enhances T cell stimulatory capacity : T-T help via APC activation
Lømo et al., Blood 1997
:
Interestingly,
IL-13 increased the expression of
CD40 on peripheral blood B cells, providing a possible mechanism for the observed synergy
Yoshimoto et al., Eur J Immunol 1997
:
Induction of
interleukin-12 p40 transcript by
CD40 ligation via activation of nuclear factor-kappaB
Séguin et al., J Infect Dis 1999
:
Sensitized lymphocytes and
CD40 ligation
augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii