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IGF2 — LEP

Text-mined interactions from Literome

Li et al., Mol Cell Endocrinol 2001 (Glioma) : In contrast, the response of the leptin promoter to insulin, IGF-1 and dibutyryl cAMP was cell-type specific and dependent on the presence or absence of FBS in the culture medium ... Insulin, IGF-1 and dibutyryl cAMP each caused an approximately two-fold stimulation of leptin promoter activity in 3T3-L1 cells under serum-free conditions, but had no significant effect in the presence of 10 % FBS
Huang et al., Zhonghua Fu Chan Ke Za Zhi 2002 : Leptin significantly inhibited FSH + IGF-I or IGF-I induced E ( 2 ) production
Garofalo et al., Clin Cancer Res 2006 (Breast Neoplasms...) : The effects of insulin, IGF-I , estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines
Nindl et al., J Appl Physiol 2007 (Body Weight...) : Total and free IGF-I, IGF binding proteins-1, -2, and -3, the acid labile subunit, transferrin, ferritin, retinol binding protein, prealbumin, testosterone, triiodothyronine, thyroxine, and leptin responses were measured
Gad et al., Saudi Med J 2007 (Diabetes Mellitus, Experimental) : Combined leptin and insulin treatment produced a significant increase of serum BAP and a decrease of urinary calcium and serum glucose as compared to rats treated by leptin only, and a significant increase of BAP, alkaline phosphates, IGF-1 , and glucose and a decrease in osteocalcin as compared to control rats
Ozbay et al., Mol Cancer Res 2008 (Breast Neoplasms) : In contrast to IGF-I, leptin did not induce phosphorylation of IGF-IR , indicating that receptor cross signaling is unidirectional, occurring from IGF-IR to Ob-R
Saxena et al., Cancer Res 2008 (Breast Neoplasms...) : We found a novel bidirectional crosstalk between leptin and IGF-I signaling ; IGF-I induced phosphorylation of leptin receptor ( Ob-Rb ) and leptin induced phosphorylation of IGF-I receptor (IGF-IR), whereas cotreatment induced synergistic phosphorylation and association of Ob-Rb and IGF-IR along with activation of downstream effectors, Akt and extracellular signal regulated kinase
Kleiman et al., Exp Mol Pathol 2013 (Hemangioma) : Elevated IGF2 prevents leptin induction and terminal adipocyte differentiation in hemangioma stem cells ... We found that IGF2 is a mitogen for hemangioma stem cells and prevents leptin induction and full terminal differentiation of hemangioma stem cells into adipocytes
Chen et al., Obes Res 1998 : These results demonstrated that regulation of leptin mRNA expression by Dex, insulin, IGF-I , TGF-beta, and GH may be associated with changes in preadipocyte number and fat cell size