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CARD11 — CHUK
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BCR signaling pathway:
IKK complex complex (CHUK-IKBKB-IKBKG)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
→
IKK alpha (CHUK)
(modification, activates)
-
Reactome Reaction:
CARD11
→
CHUK
(reaction)
Wang et al., Nature 2001, Zhou et al., Nature 2004, Shinohara et al., J Exp Med 2005, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Shinohara et al., Immunol Rev 2009, Zhang et al., Chin Med Sci J 2010
-
Reactome Reaction:
CARD11
→
CHUK
(indirect_complex)
Shinohara et al., J Exp Med 2005, Sommer et al., Immunity 2005, Shinohara et al., Immunol Rev 2009
-
WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection:
Complex of MALT1-CARD11-BCL10
→
Complex of IKBKG-IKBKB-CHUK
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Patke et al., Curr Opin Immunol 2004
:
BCR signaling leads to
activation of the
inhibitor of NF-kappa B kinase (IKK) complex via
Carma1 , Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Hara et al., J Exp Med 2004
:
Carma1 controls entry of IkappaB kinase (IKK) into lipid raft aggregates and the central region of the immune synapse, as well as activation of
IKK downstream of PKC