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MAPK7 — NA
Text-mined interactions from Literome
Lee et al., Am J Physiol 1999
:
We presently show that 1 microM 5-HT also rapidly elevates phosphorylation and activation of the
mitogen activated protein ( MAP ) kinases extracellular signal regulated kinase ( ERK ) 1 and ERK2 of SMCs, and the enhanced phosphorylation is
blocked by the antioxidants Tiron,
N-acetyl-L-cysteine (NAC) , and Ginkgo biloba extract
Park et al., Cytokine 2000
:
These differential NAC effects did not correlate with the patterns of the
mitogen activated protein kinase ( MAPK ) activation following cytokine stimulation and its
regulation by
NAC
Kyaw et al., Hypertens Res 2001
(MAP Kinase Signaling System) :
In contrast, p38
MAPK activation was
inhibited by DPI and ascorbic acid concentration-dependently, but by
NAC only at high concentration
Kuruganti et al., J Neurooncol 2002
(Astrocytoma...) :
NAC also
inhibited serum induced
MAPK activation indicating there may be an oxidant-sensitive component to serum induced growth signaling
Wang et al., Free Radic Biol Med 2003
:
The phosphorylation of p38
MAPK by V2O5 was
inhibited by
NAC and catalase, yet the EGF receptor inhibitor AG1478 had no effect on V2O5 induced p38 MAPK activation
Usatyuk et al., Antioxid Redox Signal 2003
(MAP Kinase Signaling System) :
Also,
NAC prevented H ( 2 ) O ( 2 ) - and diamide
induced p38
MAPK , but not ERK activation
Gerdjikov et al., Behav Neurosci 2004
:
Results confirmed that
NAc amphetamine
increased levels of the
MAPK extracellular signal regulated kinase ( ERK )
Han et al., Clin Exp Pharmacol Physiol 2006
:
Staurosporine ( 10 ( -6 ) mol/L ),
NAC ( 10 ( -5 ) mol/L ) and PD 98059 ( 10 ( -7 ) mol/L )
attenuated the phosphorylation of p44/42
MAPK
Lin et al., J Neurosci Res 2006
:
These results show that
NAC serially
activates ERKs and p38
MAPK , and ERKs and p38 work together to mediate the neuroprotective effect of NAC
Shastry et al., Kidney Int 2007
:
Hcy increased p38-MAPK activity ( fivefold ), with maximal effect at 50 microM and 20 min ;
p38-MAPK activation was
attenuated by
N-acetylcysteine (Nac) and catalase (Cat), further indicating that the effect was via oxidative stress ... In addition, Hcy induced apoptosis as determined by TUNEL and ssDNA assay was abrogated by
Nac , Cat, and SB203580 (
p38-MAPK inhibitor )
Huang et al., American journal of physiology. Renal physiology 2007
(Hyperglycemia...) :
It is concluded that both
NAC and taurine significantly
attenuated HG-induced activation of the
Raf-1/MAPK and the JAK2-STAT1/STAT3 signaling pathways and hypertrophic growth in renal tubular epithelial cells
Kim et al., Arch Pharm Res 2007
(Periodontitis) :
In addition,
NAC prevented LPS induced activation of p38
MAPK and JNK but not phosphorylation and subsequent degradation of IkB
Luo et al., Nephrol Dial Transplant 2008
(Acute Kidney Injury...) :
NAC blocked oxidative stress, p38
MAPK activation, caspase-3 cleavage, tissue apoptosis, renal dysfunction and morphological damage induced by CDDP
Kang et al., Oncol Rep 2008
(Uterine Cervical Neoplasms) :
In addition,
N-acetyl-L-cysteine (NAC) , a thiol containing anti-oxidant, completely
blocked p38
MAPK and JNK activations, Bax relocalization and Bcl-2 phosphorylation
Chakraborty et al., Pharmacol Res 2008
:
Also, Resveratrol was effective as an antioxidant in counteracting a rise in reactive oxygen species ( ROS ) and
p38MAPK activation by H ( 2 ) O ( 2 ) was completely
blocked by antioxidant
N-acetyl cysteine (NAC)
Wu et al., Free Radic Biol Med 2009
(MAP Kinase Signaling System) :
Activation of JNK and p38MAPK was weaker in TNFalpha plus PY-treated NOS2 ( -/- ) mice and 1400W and
NAC blocked the activation of JNK and
p38MAPK in wild-type mice
Lau et al., Br J Cancer 2010
(Adenocarcinoma...) :
Brucein D-mediated activation of
p38-MAPK was also
inhibited by
NAC
Petersen et al., Acta Physiol (Oxf) 2012
:
Analysis was conducted on the mitogen activated protein kinase signalling pathways, demonstrating that
NAC infusion
blocked the exercise induced increase in JNK phosphorylation, but not ERK1/2, or p38
MAPK
Shi et al., PloS one 2013
(Corneal Diseases...) :
In addition,
NAC completely
blocked phosphorylation of JNK and p38
MAPK induced by AGE-BSA
Kamata et al., J Biol Chem 1996
:
In parallel with the suppression of MAPK, the activation of
MAPK kinase kinase activity was also suppressed in the
presence of
NAC
Sekharam et al., Toxicol Appl Pharmacol 1998
:
NAC prevented activation of
mitogen activated protein ( MAP ) kinases p42MAPK and p44MAPK and inhibited expression of cyclin D1, but had no effect on the levels of proliferating cell nuclear antigen