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FGF4 — PRL

Text-mined interactions from Literome

Jackson et al., Mol Endocrinol 2003 (MAP Kinase Signaling System...) : We have previously characterized FGF signal transduction and regulation of the tissue-specific rat prolactin ( rPRL ) promoter in GH4 pituitary cells ... Here we demonstrate a functional role for the Rho family monomeric G protein, Rac1, in FGF regulation of PRL gene expression via an atypical signaling pathway ... FGFs failed to activate JNK1 or JNK2, and expression of dominant negative JNK or Akt constructs did not block FGF induced PRL transcription ... Consistent with the role of PKCdelta in FGF regulation of PRL gene expression, activation of the rPRL promoter was blocked by an inhibitor of phospholipase Cgamma ( PLCgamma ) activity ... These results suggest that FGF-2 and FGF-4 activate PRL gene expression via a novel Rac1, PLCgamma, PKCdelta, and ERK cascade, independent of phosphoinositol-3-kinase and JNK
Spuch et al., Endocrine 2006 : In cells from in vivo E2-treated rats, FGF-2 increased ( > 50 % ) the PRL secretion in response to TRH, while EGF reduced responses to high doses of TRH ( 10 ( -6 ), 10 ( -5 ) M )
Spuch et al., Endocrine 2007 : In addition, FGF-2 and EGF, two important growth factors present in the pituitary, reduced the PrRP induced prolactin increase in vitro
Larson et al., Endocrinology 1990 : Basic FGF reduced ( P less than 0.0001 ) the mean basal secretion of prolactin per lactotroph ... Basic FGF blocked the TRH induced increase in PRL secretion
Shimon et al., J Clin Invest 1996 (Neoplasm Invasiveness...) : FGF-4 ( 0.1-50 ng/ml ) caused a dose dependent 2.5-fold increase of prolactin (PRL) secretion ( P < 0.001 ) in GH4 cells and up to 60 % ( P < 0.05 ) in primary cultures, while decreasing growth hormone release ( P < 0.001 ) ... The results indicate that hst overexpression mediates lactotrope tumor growth and potently stimulates PRL synthesis
Mallo et al., Mol Cell Endocrinol 1995 : In the present report we have studied the effects of acidic and basic molecular forms of the fibroblast growth factor ( aFGF, bFGF ) on prolactin (PRL) mRNA production and PRL secretion in GH3 cells, a rat pituitary cell line, and their interactions with 17 beta-estradiol ( beta E2 )
Cho et al., Anim Reprod Sci 1998 : Although HST reduced PRL secretion, it did not abolish the effect of seasonal changes ( P < 0.01 ) ; circulating PRL concentration increased six-fold by shifts in photoperiod and temperature from winter to summer in these stalk transected calves