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ITGB1 — PXN

Pathways - manually collected, often from reviews:

• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → PIP2/Gelsolin complex (GSN) (actin filament polymerization, collaborate)
  
• BioCarta ucalpain and friends in cell spread: FODRIN (SPTAN1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Calpain1 complex (CAPNS1-CAPN1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, activates)
  
• BioCarta ucalpain and friends in cell spread: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, collaborate)
  
• BioCarta integrin signaling pathway: None → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: Zyxin (ZYX) → ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) (modification, collaborate)
  
• BioCarta integrin signaling pathway: Zyxin (ZYX) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: CSK → ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) (modification, collaborate)
  
• BioCarta integrin signaling pathway: CSK → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Tensin (TNS1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → FAK (PTK2) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → NOLC1 (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Calpain1 (CAPN1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Actin (ACTA1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Tensin (TNS1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → FAK (PTK2) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → NOLC1 (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Calpain1 (CAPN1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Actin (ACTA1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → utrophin (UTRN) (modification, collaborate)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: utrophin (UTRN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Calpastatin (CAST) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, inhibits)
  
• BioCarta mcalpain and friends in cell motility: Actin (ACTA1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Calpain1 complex (CAPNS1-CAPN1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, activates)
  
• BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) (actin filament polymerization, activates)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, activates)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Paxillin/FAK/Talin/MLC/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → myosin light chain protein kinase (MYLK) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-TLN1-ITGB1) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) (modification, collaborate)
• BioCarta integrin signaling pathway: Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-TLN1-ITGB1) (modification, collaborate)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → cortactin (CTTN) (modification, collaborate)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: cortactin (CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: RAC1 → Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) (modification, activates)
  
• BioCarta ucalpain and friends in cell spread: Talin (TLN1) → Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → FODRIN (SPTAN1) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Actin (ACTA1) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Ezrin (VIL2) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → PAX (PXN) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → PAX (PXN) (modification, collaborate)
• BioCarta mcalpain and friends in cell motility: Calpastatin (CAST) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, inhibits)
  
• BioCarta mcalpain and friends in cell motility: Actin (ACTA1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Ezrin (VIL2) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, activates)
  
• BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: MLC (MLC1) → Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Calpain2 complex (CAPNS1-CAPN2) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Calpastatin (CAST) (modification, collaborate)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• KEGG Focal adhesion: PXN → Complex of 21 proteins (protein-protein, binding/association)
• NCI Pathway Database Alpha4 beta1 integrin signaling events: None → alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: CDC42/GDP complex () → alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) → None (modification, activates) Deakin et al., J Cell Sci 2009
  Evidence: mutant phenotype
• NCI Pathway Database CXCR4-mediated signaling events: alpha-beta1 Integrin (ITGA8/ITGB1/ITGA10/ITGB1/ITGA6/ITGB1/ITGA1/ITGB1/ITGA3/ITGB1/ITGA2/ITGB1/ITGAV/ITGB1/ITGA11/ITGB1/ITGA4/ITGB1/ITGA7/ITGB1/ITGA5/ITGB1/ITGA9/ITGB1) → FAK/p130 Cas/Paxillin complex (PTK2-BCAR1-PXN) (cell adhesion, collaborate)
  Okabe et al., J Hematother Stem Cell Res 2002, Glodek et al., Leukemia 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Type I PKA complex (PRKACA-PRKAR1A-PRKAR1B-PRKACB) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, activates)
  Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Paxillin (PXN) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: alpha9/beta1 Integrin/Tenascin C/Paxillin complex (PXN-ITGA9-ITGB1-TNC) → Paxillin (PXN) (modification, collaborate) Young et al., Mol Biol Cell 2001*
  Evidence: physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: alpha9/beta1 Integrin/Tenascin C/Paxillin complex (PXN-ITGA9-ITGB1-TNC) → alpha9/beta1 Integrin/Tenascin C complex (ITGA9-ITGB1-TNC) (modification, collaborate)
  Young et al., Mol Biol Cell 2001*
  Evidence: physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: Paxillin (PXN) → alpha9/beta1 Integrin/Tenascin C complex (ITGA9-ITGB1-TNC) (modification, collaborate)
  Young et al., Mol Biol Cell 2001*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Hyduk et al., Blood 2004*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Hyduk et al., Blood 2004*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Paxillin (PXN) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Hyduk et al., Blood 2004*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → Talin (TLN1) (modification, collaborate) Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Talin (TLN1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → FAK (PTK2) (modification, activates) Rose et al., J Immunol 2003, Nojima et al., Cell Immunol 1995*, Manie et al., Blood 1996
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Han et al., J Biol Chem 2001, Liu et al., J Biol Chem 2002*, Goldfinger et al., J Cell Biol 2003, Kummer et al., J Biol Chem 2010*
  Evidence: assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Han et al., J Biol Chem 2001, Liu et al., J Biol Chem 2002*, Goldfinger et al., J Cell Biol 2003, Kummer et al., J Biol Chem 2010*
  Evidence: assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) → YWHAZ/YWHAZ complex (YWHAZ) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → PYK2 (PTK2B) (modification, activates) Kanda et al., Biochem Biophys Res Commun 2003*, Rose et al., J Immunol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → Paxillin (PXN) (modification, collaborate) Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Paxillin (PXN) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ITGB1 — PXN (physical association, affinity chromatography technology) Chen et al., J Neurosci 2000*
• IRef Hprd Interaction: Complex of PXN-ITGA4-PXN-PXN-ITGA4-ITGB1-ITGA4-ITGB1-ITGB1 (in vivo) Pinco et al., Mol Biol Cell 2002*
• IRef Hprd Interaction: PXN — ITGB1 (in vitro) Chen et al., J Neurosci 2000*, Schaller et al., J Cell Biol 1995*
• IRef Hprd Interaction: PXN — ITGB1 (in vivo) Chen et al., J Neurosci 2000*, Schaller et al., J Cell Biol 1995*
• IRef Intact Interaction: Complex of 13 proteins (association, anti bait coimmunoprecipitation) Liu et al., Nature 1999
• IRef Intact Interaction: Complex of PXN-ITGB1-ITGA5-FN1 (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of ITGB1-PXN-ITGA4-VCAM1 (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: ITGB1 — PXN (physical association, anti bait coimmunoprecipitation) Liu et al., Nature 1999
• IRef Ophid Interaction: ITGB1 — PXN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ITGB1 — PXN (aggregation, confirmational text mining) Chen et al., J Neurosci 2000*

Text-mined interactions from Literome

Lu et al., Mol Pharmacol 2006 : Compared with docetaxel, laulimalide more potently caused a reduction in the constitutive levels ( i.e., in the absence of VEGF ) of phosphorylated paxillin and more potently inhibited the association of RhoA with the alpha5beta1 integrin
Manevich et al., J Biol Chem 2007 : Talin 1, but not paxillin , was required for VLA-4 to undergo optimal stimulation by the prototypic chemokine, CXCL12, under shear stress conditions