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CISH — IRF6
Text-mined interactions from Literome
Crespo et al., Eur J Immunol 2002
(MAP Kinase Signaling System) :
These observations are mechanistically consistent with the known
induction of
suppressors of cytokine signaling (SOCS)-1 and SOCS-3 proteins by
LPS
Kinjyo et al., Immunity 2002
:
We show here that the
suppressor of cytokine-signaling-1 ( SOCS1/JAB ) is rapidly
induced by
LPS and negatively regulates LPS signaling
Tassiulas et al., Hum Immunol 2007
(MAP Kinase Signaling System) :
Apoptotic cells had minimal effects on
LPS induced activation of NF-kappaB and MAPKs, but induced expression of
SOCS proteins and substantially suppressed induction of CXCL10 expression by IFN-alpha
Hu et al., J Immunol 2009
(Cryptosporidiosis...) :
Using in vitro models using normal human biliary epithelial cells ( cholangiocytes ), we demonstrated that
LPS stimulation or infection with the parasitic protozoan Cryptosporidium parvum
induced expression of
CIS protein without a change in CIS mRNA levels by activating the TLR signaling pathway
Wang et al., Fish Shellfish Immunol 2010
(Fish Diseases...) :
However, PMA stimulation did impact on SOCS6 and SOCS9 expression, and
LPS stimulation of primary cultures or bacterial infection ( Yersinia ruckeri )
increased significantly
CISH expression ( as well as SOCS1 and SOCS2 or SOCS3 respectively )
Ban et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011
:
Interestingly, among genes related to macrophage mediated immunity,
LPS increased the expression of seven genes ( Adora2b, Fcgr2b,
Cish , Cxcl10, Clec4n, Il1a, and Il1b ) and decreased the expression of one gene ( Clec4a3 )
Kerr et al., Neuroscience 2012
:
URB597 attenuated the LPS induced increase in interleukin (IL)-1ß expression while concurrently augmenting the
LPS induced increase in
suppressor of cytokine signalling (SOCS)-3 expression
Yang et al., Exp Physiol 2012
(Asthma...) :
Parallel to the alteration of degranulation,
LPS increased FceRI activated Ca ( 2+ ) mobilization, as well as Ca ( 2+ ) entry through
store operated calcium channels (SOCs) evoked by thapsigargin
Minogue et al., Journal of neuroinflammation 2012
(MAP Kinase Signaling System) :
Co-treatment of glia with LPS and recombinant IL-6 protein attenuated the LPS induced release of both TNF a and IL-1 ß while potentiating the
effect of
LPS on
suppressor of cytokine signaling (SOCS)3 expression and IL-10 release
Kim et al., J Clin Invest 2013
(Lupus Erythematosus, Systemic) :
Let-7c reciprocally inhibited Blimp1 and also blocked
LPS induced
suppressor of cytokine signaling-1 ( SOCS1 ) expression, contributing to the proinflammatory phenotype of Blimp1-deficient DCs