Gene interactions and pathways from curated databases and text-mining

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EDN1 — IRF6

Text-mined interactions from Literome

Xu et al., Acta Pharmacol Sin 2001 : Lipopolysaccharide (LPS) 10 mg/L increased the proliferation and endothelin release in cultured mesangial cells
Treffkorn et al., Prostaglandins Other Lipid Mediat 2004 : Lipopolysaccharide (LPS) induces a release of tumor necrosis factor (TNF)-alpha, endothelin (ET)-1 , interleukin (IL)-1alpha, IL-6 and IL-10 in rat liver macrophages ( Kupffer cells )
Duan et al., J Ethnopharmacol 2006 : We investigated the effect of anemonin on the release of nitric oxide ( NO ), endothelin-1 (ET-1) and soluble intercellular adhesion molecule-1 ( sICAM-1 ) induced by lipopolysaccharide (LPS) in primary cultures of rat intestinal microvascular endothelial cells ( RIMECs )
Yang et al., Inflammation 2007 : The effects of cyclic AMP related compounds and beta adrenoceptor agonists on the basal and lipopolysaccharide (LPS) stimulated release of endothelin-1 (ET-1) from guinea-pig tracheal epithelial cells ( GPTEpCs ) in culture were studied
Wang et al., American journal of physiology. Renal physiology 2009 (Acute Kidney Injury...) : Ghrelin administration ( 1.0 mg/kg sc 6 h and 30 min before and 14 h after LPS ) significantly decreased serum cytokine levels ( TNF-alpha, IL-1beta, and IL-6 ) and serum endothelin-1 levels which had been induced by LPS
Schnabl et al., J Pediatr Gastroenterol Nutr 2009 (Anoxia...) : Ganglioside preexposure reduced bowel necrosis and endothelin-1 production in response to LPS
Talati et al., Am J Physiol Lung Cell Mol Physiol 2010 (Hypertension, Pulmonary) : In control BMDM, LPS resulted in increased ppET-1 gene expression and ET-1 in culture media, whereas ET ( A ) and ET ( B ) receptor and ECE gene expression was decreased
Kitagawa et al., Am J Physiol Gastrointest Liver Physiol 2013 (Reperfusion Injury) : In the experiment using isolated Kupffer cells, the expression of interleukin-6, interleukin-1ß, and endothelin-1 in response to LPS stimulation was attenuated by BCAA in a dose dependent fashion
Shakespear et al., J Biol Chem 2013 (Inflammation) : Both LPS and Hdac7-u up-regulated the activity of the Edn1 promoter in an HDAC dependent fashion in RAW264 cells
Gardiner et al., Br J Pharmacol 1995 : A possible explanation of this observation is that LPS increased circulating endothelin levels, and thus resulted in desensitization to the effects of endothelin released following administration of L-NMMA
Ros et al., J Hepatol 1997 : The aim of the study was to investigate the effect of bacterial lipopolysaccharide (LPS) on endothelin-1 synthesis and release in cultured human vascular endothelial cells ( HUVEC )
Shindo et al., J Cardiovasc Pharmacol 1998 (Shock, Septic) : In this study we examined the effect of LPS on the gene expression of endothelin-1 (ET-1) and adrenomedullin (AM), two major vasoactive peptides predominantly produced by vascular endothelial cells, to investigate their role in the pathophysiology of septic shock
Salh et al., Immunology 1998 (Crohn Disease) : The objective of this study was to characterize the role of various cytokines, bacterial lipopolysaccharide (LPS) and colony stimulating factors on the production of endothelin ( ET ) by freshly isolated human monocytes