◀ Back to IRF6
IRF3 — IRF6
Pathways - manually collected, often from reviews:
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
Text-mined interactions from Literome
Juang et al., J Biol Chem 1999
:
Furthermore,
LPS inhibited virus mediated phosphorylation of interferon regulatory factor (IRF)-3 and the consequent translocation of
IRF-3 from cytoplasm to nucleus
Ohmori et al., J Leukoc Biol 2001
:
Activation of these STAT1 containing transcription factors was mediated by the intermediate induction of type I IFNs, since the
LPS induced IP-10,
IRF-1 , and iNOS mRNA expression was markedly reduced in macrophages from IFN-alpha/betaR-/- mice and blocked by cotreatment with antibodies against type I IFN
Sakaguchi et al., Biochem Biophys Res Commun 2003
:
Although much has been studied about the activation of the transcription factor IRF-3 and induction of IFN-beta gene by the LPS mediated TLR4 signaling, definitive evidence is missing about the actual
role of
IRF-3 in
LPS responses in vitro and in vivo
Dang et al., J Immunol 2004
:
In this study, we demonstrate that the
LPS mediated activation of
IRF3 and subsequent induction of chemokine genes or IRF3-responsive reporter constructs are inhibited after exposure of human or murine macrophages to the Bacillus anthracis toxin lethal factor
Dang et al., Shock 2004
(Inflammation...) :
Here we show that the hydroxystilbene piceatannol inhibits the
LPS mediated activation of
IRF3 and subsequent ISG induction
Marson et al., J Biol Chem 2004
(Inflammation) :
Inspection of the LPS induced activation state of several transcription factors known to play a prominent role in IFNbeta transcription reveals that, although NFkappaB, c-Jun, and ATF-2 activation appears normal, the
LPS induced activation of
IFNbeta regulatory factor 3 (IRF3) , as measured by DNA binding activity and association with the coactivator CBP, is inhibited in the OxLDL pre treated cells
Hemmi et al., J Exp Med 2004
(Virus Diseases) :
Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA ( dsRNA )
induce phosphorylation of
interferon ( IFN ) regulatory factor (
IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction ... Viral infection and stimulation with
lipopolysaccharide (LPS) or double stranded RNA ( dsRNA )
induce phosphorylation of
interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction ... Viral infection and stimulation with
lipopolysaccharide (LPS) or double stranded RNA ( dsRNA )
induce phosphorylation of interferon ( IFN ) regulatory factor (
IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction
Takeuchi et al., J Endotoxin Res 2004
:
Activation of
IFN-regulatory factor (IRF) 3 in
response to
LPS and poly ( I:C ) was abolished in IKK-i/TBK1 doubly deficient cells
Pålsson-McDermott et al., Immunology 2004
:
A later response to
LPS makes use of TIR-domain containing adapter inducing interferon-beta ( TRIF ) and TRIF related adapter molecule (TRAM), and
leads to the late activation of NF-kappaB and
IRF3 , and to the induction of cytokines, chemokines, and other transcription factors
Nencioni et al., Blood 2006
:
As a suitable mechanism for these effects, bortezomib was found to down-regulate MyD88, an essential adaptor for TLR signaling, and to relieve
LPS induced activation of NF-kappaB,
IRF-3 , and IRF-8 and of the MAP kinase pathway
Youn et al., Biochem Pharmacol 2006
:
LPS induces the activation of NF-kappaB and
IRF3 through MyD88- or TRIF dependent pathways ... Curcumin also inhibited
LPS induced
IRF3 activation
Youn et al., Biochem Pharmacol 2006
:
EGCG inhibited the activation of
IFN regulatory factor 3 (IRF3) induced by
LPS , poly [ I:C ], or the overexpression of TRIF
Bibeau-Poirier et al., J Immunol 2006
(Virus Diseases) :
In agreement with this observation,
IRF-3 is recruited to Cullin1 following virus infection and overexpression of a dominant negative mutant of Cullin1 significantly
inhibits the degradation of
IRF-3 observed in infected cells
Aksoy et al., Blood 2007
:
Although
LPS induced
IRF-3 nuclear translocation was observed both in adult and neonatal moDCs, IRF-3 DNA binding activity and association with the coactivator CREB binding protein (CBP) were decreased in neonatal as compared with adult moDCs
Ock et al., J Neurosci Res 2007
(Inflammation) :
Hypoxia, however, differentially regulated MyD88 dependent and -independent pathways of TLR4 signaling : Hypoxia
enhanced lipopolysaccharide (LPS) induced
interferon regulatory factor-3 (IRF-3) activation and the subsequent expression of IFNbeta ( MyD88 independent pathway ), whereas it suppressed
LPS induced NF-kappaB activation ( MyD88 dependent pathway )
Reimer et al., J Immunol 2007
(Listeriosis) :
In contrast, vesicular stomatitis virus and
LPS triggered
IRF3 activation and signaling
Youn et al., Biochem Pharmacol 2008
:
Our results showed that cinnamaldehyde suppressed the activation of NFkappaB and
IRF3 induced by
LPS , a TLR4 agonist, leading to the decreased expression of target genes such as COX-2 and IFNbeta in macrophages ( RAW264.7 )
Reimer et al., J Leukoc Biol 2008
:
poly ( I:C ) and
LPS induce distinct
IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages
Youn et al., Int Immunopharmacol 2008
:
Selenium inhibited
IRF3 activation
induced by poly [ I:C ],
LPS or the overexpression of TRIF or TBK1
Abe et al., Arterioscler Thromb Vasc Biol 2008
(Inflammation...) :
Statins inhibited TLR4 mediated
activation of
interferon ( IFN ) regulatory factor ( IRF)3 by either
lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
McCoy et al., J Biol Chem 2008
:
IRF3 can be activated by Toll-like receptor 3 (TLR3) in response to the double stranded RNA mimic poly ( I-C ) and by TLR4 in
response to
lipopolysaccharide (LPS) ... It also inhibited increased phosphorylation of
IRF3 in its N terminus in
response to
LPS and in its C terminus on Ser-396 in response to either poly ( I-C ) or LPS
Daffis et al., J Virol 2008
(Viremia...) :
In cell culture, many RNA viruses trigger IFN responses through the binding of RNA recognition molecules ( RIG-I, MDA5, and TLR-3 ) and induction of
interferon regulatory factor IRF-3 dependent gene transcription
Park et al., Biosci Biotechnol Biochem 2009
:
Our goal was to identify the molecular target of 6-shogaol in the TRIF dependent pathway of TLRs. 6-Shogaol inhibited the activation of
interferon-regulatory factor 3 (IRF3) induced by
lipopolysaccharide (LPS) and by polyriboinosinic polyribocytidylic acid ( poly [ I:C ] ), overexpression of TRIF, TANK binding kinase1 (TBK1), and IRF3
Sweeney et al., J Immunol 2010
(Arthritis, Rheumatoid) :
IRF3 regulates IFN stimulated response element ( ISRE ) promoter activity as well as IFN-beta,
IRF5 , IRF7, RANTES, IFN-inducible protein-10, MCP-1, and MIP1alpha gene expression in response to poly ( I-C )
Into et al., Cell Immunol 2010
(Bacterial Infections...) :
LL-37 potently suppressed
LPS induced gene expression of IL6, IL8 and CXCL10 and intracellular signaling events, degradation of IRAK-1 and IkappaBalpha and phosphorylation of p38 MAPK and
IRF3 , indicating that the LPS neutralizing activity is also exerted in HGFs. LL-37 also suppressed the expression of IL6, IL8 and CXCL10 induced by the TLR3 ligand poly ( I:C )
Ogasawara et al., Journal of clinical biochemistry and nutrition 2011
:
Rebamipide reduced the expression of TBK1,
IRF3 and IRF7 mRNA
induced by
LPS/dsRNA , but not of NF-?B mRNA in colonic epithelial cells
He et al., Eur J Immunol 2011
(Listeriosis...) :
Conversely, overexpression of CLIC4 enhanced
LPS mediated
IRF3
Sugiyama et al., Mol Immunol 2012
:
Further, we examined the effect of 2-AP on
LPS induced
IRF-3 activation by immunoblotting ... While 2-AP did not affect
LPS induced phosphorylation of
IRF-3 , nuclear translocation of IRF-3 was inhibited
Ke et al., Hepatology 2013
(Disease Models, Animal...) :
In contrast, knockdown of ß-catenin increased PTEN/TLR4 ( Toll-like receptor 4 ),
interferon regulatory factor-3 (IRF3), nuclear factor kappa B ( NF-?B ) activity, and proinflammatory cytokine programs in
response to
LPS stimulation
Etoh et al., Eur J Pharmacol 2013
:
However, it showed no effect on
LPS induced nuclear translocation of
interferon regulatory factor (IRF)-3 , a MyD88 independent signaling molecule
Kim et al., Br J Pharmacol 2013
:
The inhibitory effect on
LPS induced
IRF3 activation by CAPE was not observed when 293T cells were reconstituted with MD2 ( C133S ) mutant
Faure et al., J Biol Chem 1999
:
The decrease of
LPS/IFN-gamma induced IRF-1 promoter activity,
IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds