◀ Back to ITGB1
ITGB1 — VCAM1
Pathways - manually collected, often from reviews:
-
KEGG Cell adhesion molecules (CAMs):
Complex of ITGA4-ITGB1
→
VCAM1
(protein-protein, activation)
-
KEGG Cell adhesion molecules (CAMs):
Complex of ITGA9-ITGB1
→
VCAM1
(protein-protein, activation)
-
KEGG Leukocyte transendothelial migration:
VCAM1
→
Complex of ITGA4-ITGB1
(protein-protein, binding/association)
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
LRP (PTPRA)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, activates)
Pereira et al., J Immunol 2001, Hsia et al., Mol Cell Biol 2005
Evidence: mutant phenotype
-
NCI Pathway Database Beta1 integrin cell surface interactions:
VCAM1 (VCAM1)
→
alpha4/beta1 Integrin complex (ITGA4-ITGB1)
(modification, collaborate)
Sriramarao et al., Blood 2000*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Beta1 integrin cell surface interactions:
VCAM1 (VCAM1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Sriramarao et al., Blood 2000*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Beta1 integrin cell surface interactions:
alpha4/beta1 Integrin complex (ITGA4-ITGB1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Sriramarao et al., Blood 2000*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database a4b7 Integrin signaling:
alpha4/beta1 Integrin/Paxillin/VCAM1 complex (ITGB1-VCAM1)
→
VCAM1 (VCAM1)
(modification, collaborate)
Abonia et al., Blood 2006*, Pinola et al., Scand J Immunol 1994*, Postigo et al., J Immunol 1993
-
NCI Pathway Database a4b7 Integrin signaling:
alpha4/beta1 Integrin/Paxillin/VCAM1 complex (ITGB1-VCAM1)
→
alpha4/beta7 Integrin/Paxillin complex (ITGB7)
(modification, collaborate)
Abonia et al., Blood 2006*, Pinola et al., Scand J Immunol 1994*, Postigo et al., J Immunol 1993
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
VCAM1 (VCAM1)
→
alpha4/beta1 Integrin complex (ITGA4-ITGB1)
(modification, collaborate)
Hsia et al., Mol Cell Biol 2005, Ring et al., Proc Natl Acad Sci U S A 2011
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
VCAM1 (VCAM1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Hsia et al., Mol Cell Biol 2005, Ring et al., Proc Natl Acad Sci U S A 2011
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin complex (ITGA4-ITGB1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Hsia et al., Mol Cell Biol 2005, Ring et al., Proc Natl Acad Sci U S A 2011
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1)
→
Talin (TLN1)
(modification, collaborate)
Alon et al., J Cell Biol 2005
Evidence: mutant phenotype
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1)
→
alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1)
(modification, collaborate)
Alon et al., J Cell Biol 2005
Evidence: mutant phenotype
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
Talin (TLN1)
→
alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1)
(modification, collaborate)
Alon et al., J Cell Biol 2005
Evidence: mutant phenotype
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1)
→
FAK (PTK2)
(modification, activates)
Rose et al., J Immunol 2003, Nojima et al., Cell Immunol 1995*, Manie et al., Blood 1996
Evidence: mutant phenotype
-
NCI Pathway Database Beta1 integrin cell surface interactions:
VCAM1 (VCAM1)
→
alpha9/beta1 Integrin complex (ITGA9-ITGB1)
(modification, collaborate)
Taooka et al., J Cell Biol 1999*, Palmer et al., J Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database Beta1 integrin cell surface interactions:
VCAM1 (VCAM1)
→
alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1)
(modification, collaborate)
Taooka et al., J Cell Biol 1999*, Palmer et al., J Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database Beta1 integrin cell surface interactions:
alpha9/beta1 Integrin complex (ITGA9-ITGB1)
→
alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1)
(modification, collaborate)
Taooka et al., J Cell Biol 1999*, Palmer et al., J Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
ABI1 (ABI1)
→
alpha4/beta1 Integrin/VCAM1/ABI1 complex (VCAM1-ABI1-ITGA4-ITGB1)
(modification, collaborate)
Ring et al., Proc Natl Acad Sci U S A 2011
Evidence: assay
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
ABI1 (ABI1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Ring et al., Proc Natl Acad Sci U S A 2011
Evidence: assay
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/ABI1 complex (VCAM1-ABI1-ITGA4-ITGB1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Ring et al., Proc Natl Acad Sci U S A 2011
Evidence: assay
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1)
→
PYK2 (PTK2B)
(modification, activates)
Kanda et al., Biochem Biophys Res Commun 2003*, Rose et al., J Immunol 2003
Evidence: mutant phenotype
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1)
→
Paxillin (PXN)
(modification, collaborate)
Alon et al., J Cell Biol 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Alon et al., J Cell Biol 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
Paxillin (PXN)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Alon et al., J Cell Biol 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Alpha9 beta1 integrin signaling events:
VCAM1 (VCAM1)
→
alpha9/beta1 Integrin complex (ITGA9-ITGB1)
(modification, collaborate)
Taooka et al., J Cell Biol 1999*
Evidence: physical interaction
-
NCI Pathway Database Alpha9 beta1 integrin signaling events:
VCAM1 (VCAM1)
→
alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1)
(modification, collaborate)
Taooka et al., J Cell Biol 1999*
Evidence: physical interaction
-
NCI Pathway Database Alpha9 beta1 integrin signaling events:
alpha9/beta1 Integrin complex (ITGA9-ITGB1)
→
alpha9/beta1 Integrin/VCAM1 complex (VCAM1-ITGA9-ITGB1)
(modification, collaborate)
Taooka et al., J Cell Biol 1999*
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin/Thrombospondin complex (ITGA4-ITGB1-THBS1)
→
VCAM1 (VCAM1)
(modification, collaborate)
Li et al., J Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
VCAM1 (VCAM1)
→
alpha4/beta1 Integrin complex (ITGA4-ITGB1)
(modification, collaborate)
Li et al., J Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
VCAM1 (VCAM1)
→
alpha4/beta1 Integrin complex (ITGA4-ITGB1)
(modification, collaborate)
Sriramarao et al., Blood 2000*, Sengbusch et al., J Cell Biol 2002*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Chigaev et al., J Immunol 2007*, Lomakina et al., Biophys J 2009*, García-Bernal et al., Immunity 2009*, Jakubowski et al., Cell adhesion and communication 1995*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
VCAM1 (VCAM1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Sriramarao et al., Blood 2000*, Sengbusch et al., J Cell Biol 2002*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Chigaev et al., J Immunol 2007*, Lomakina et al., Biophys J 2009*, García-Bernal et al., Immunity 2009*, Jakubowski et al., Cell adhesion and communication 1995*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
Evidence: physical interaction
-
NCI Pathway Database Alpha4 beta1 integrin signaling events:
alpha4/beta1 Integrin complex (ITGA4-ITGB1)
→
alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1)
(modification, collaborate)
Sriramarao et al., Blood 2000*, Sengbusch et al., J Cell Biol 2002*, Kovach et al., J Cell Biol 1992*, Rosen et al., Cell 1992*, Abonia et al., Blood 2006*, Elices et al., Cell 1990*, Chigaev et al., J Immunol 2007*, Lomakina et al., Biophys J 2009*, García-Bernal et al., Immunity 2009*, Jakubowski et al., Cell adhesion and communication 1995*, Masumoto et al., J Cell Biol 1993*, Werfel et al., Am J Respir Cell Mol Biol 1996*
Evidence: physical interaction
-
Reactome Reaction:
ITGB1
→
VCAM1
(indirect_complex)
Taooka et al., J Cell Biol 1999*, Yusuf-Makagiansar et al., Med Res Rev 2002*, Jones et al., Nature 1995*
-
Reactome Reaction:
ITGB1
→
VCAM1
(reaction)
Taooka et al., J Cell Biol 1999*, Yusuf-Makagiansar et al., Med Res Rev 2002*, Jones et al., Nature 1995*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
MIPS CORUM ITGA4-ITGB1-VCAM1 complex:
ITGA4-ITGB1-VCAM1 complex complex (ITGA4-ITGB1-VCAM1)
Chan et al., J Immunol 2000*
-
MIPS CORUM ITGA9-ITGB1-VCAM1 complex:
ITGA9-ITGB1-VCAM1 complex complex (ITGA9-ITGB1-VCAM1)
Taooka et al., J Cell Biol 1999*
-
IRef Corum Interaction:
Complex of ITGA9-VCAM1-ITGB1
(association, affinity chromatography technology)
Taooka et al., J Cell Biol 1999*
-
IRef Corum Interaction:
Complex of ITGB1-ITGA4-VCAM1
(association, affinity chromatography technology)
Chan et al., J Immunol 2000*
-
IRef Hprd Interaction:
Complex of ITGB1-VCAM1-ITGA9-VCAM1-ITGB1-ITGA9-ITGA9-ITGB1-VCAM1
(in vivo)
Taooka et al., J Cell Biol 1999*
-
IRef Hprd Interaction:
ITGB1
—
VCAM1
(in vitro)
Crook et al., J Vasc Res 2002*, Abe et al., J Bone Miner Metab 2009*
-
IRef Hprd Interaction:
ITGB1
—
VCAM1
(in vivo)
Crook et al., J Vasc Res 2002*, Abe et al., J Bone Miner Metab 2009*
-
IRef Hprd Interaction:
Complex of ITGB1-VCAM1-ITGA4-VCAM1-ITGB1-ITGA4-ITGA4-ITGB1-VCAM1
(in vivo)
Chan et al., J Immunol 2000*, Domínguez-Jiménez et al., Cell adhesion and communication 1996*
-
IRef Intact Interaction:
ITGB1
—
VCAM1
(physical association, cross-linking study)
Humphries et al., Science signaling 2009
-
IRef Intact Interaction:
Complex of 185 proteins
(association, cross-linking study)
Humphries et al., Science signaling 2009
-
IRef Intact Interaction:
Complex of ITGB1-PXN-ITGA4-VCAM1
(association, cross-linking study)
Humphries et al., Science signaling 2009
-
IRef Intact Interaction:
Complex of TLN1-ITGB1-VCAM1-ZYX
(association, pull down)
Byron et al., Proteomics 2012
-
IRef Intact Interaction:
Complex of 177 proteins
(association, cross-linking study)
Byron et al., Proteomics 2012
-
IRef Intact Interaction:
Complex of 168 proteins
(association, cross-linking study)
Byron et al., Proteomics 2012
-
IRef Intact Interaction:
Complex of 203 proteins
(association, cross-linking study)
Byron et al., Proteomics 2012
-
IRef Ophid Interaction:
ITGB1
—
VCAM1
(aggregation, confirmational text mining)
Chan et al., J Immunol 2000*
-
IRef Ophid Interaction:
ITGB1
—
VCAM1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Chuang et al., Blood 2004
:
By using monoclonal antibodies and recombinant intercellular adhesion molecule 1 ( ICAM-1 ) to engage lymphocyte function associated antigen 1 ( LFA-1 ) on monocytic cells, we found that the cellular adhesion to
vascular cell adhesion molecule 1 ( VCAM-1 )
mediated by
very late antigen 4 (VLA-4) was suppressed after this treatment and the suppression depended on the presence of reactive oxygen species ( ROSs )
Miura et al., Pediatr Infect Dis J 2004
(Coronary Aneurysm...) :
Our results suggest that E-selectin and
VCAM-1 expression on neovasculature may contribute to neoangiogenesis and prolonged CAA inflammation and that
integrin beta1 might be
involved in fibroblastic remodeling of acute KD CAA
Sasaki et al., J Immunother 2009
(Melanoma, Experimental) :
Predictably, among the Th populations evaluated, Th1 cells alone adhered efficiently to, and were costimulated by, plate bound
VCAM-1 and laminin in a
VLA-4 dependent or VLA-6 dependent manner, respectively
Nakajima et al., J Exp Med 1994
:
These results indicate that
VCAM-1/VLA-4 interaction plays a predominant role in controlling antigen induced eosinophil and T cell recruitment into the tissue and that the induction of
VCAM-1 expression on the endothelium at the site of allergic inflammation
regulates this eosinophil and T cell recruitment
van Seventer et al., Eur J Immunol 1998
:
Stimulation of Jurkat T cells with the
alpha4beta1 integrin ligand VCAM-1 results in Pyk2 tyrosine phosphorylation, and combined
stimulation with
VCAM-1 and anti-CD3 mAb induces rapid and sustained synergistic Pyk2 phosphorylation