◀ Back to RHOA
KDR — RHOA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
RHOA
→
KDR
(increases, KDR Activity, RHOA Activity)
Zeng et al., J Biol Chem 2003*
Evidence: Our most recent works show that pertussis toxin-sensitive G proteins and Gbetagamma subunits are required for Flt-1-mediated down-regulation of human umbilical vein endothelial cell (HUVEC) proliferation and that Gq/11 proteins are required for KDR-mediated RhoA activation and HUVEC migration.
-
NCI Pathway Database Integrins in angiogenesis:
Hsp90 (HSP90AA1)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
ROCK (ROCK1)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
RhoA (RHOA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA)
→
RhoA (RHOA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
RHOA/GDP complex (RHOA)
→
VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3)
(modification, collaborate)
Le Boeuf et al., J Biol Chem 2004
Evidence: mutant phenotype
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
FAK (PTK2)
(modification, activates)
Le Boeuf et al., Mol Biol Cell 2006, Abedi et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
RHOA
→
KDR
(reaction)
Le Boeuf et al., Mol Biol Cell 2006
Text-mined interactions from Literome
Gingras et al., Biochem J 2000
:
Transient overexpression of a dominant-active
RhoA mutant also
induced an increase in the tyrosine phosphorylation of the
VEGFR-2 , whereas overexpression of a dominant-inactive form of the protein was without effect
Zeng et al., J Biol Chem 2003
:
Our most recent works show that pertussis toxin-sensitive G proteins and Gbetagamma subunits are required for Flt-1 mediated down-regulation of human umbilical vein endothelial cell ( HUVEC ) proliferation and that Gq/11 proteins are required for
KDR mediated
RhoA activation and HUVEC migration
Sivaraj et al., Dev Cell 2013
(Neovascularization, Pathologic) :
G13 mediated
VEGFR-2 expression
involved activation of the small GTPase
RhoA and transcription factor NF-?B, the latter acting via a specific binding site at position -84 of the VEGFR-2 promoter