◀ Back to PCNA

ORC1 — PCNA

Text-mined interactions from Literome

Findeisen et al., Eur J Biochem 1999 : Cyclin A-dependent kinase activity affects chromatin binding of ORC , Cdc6, and MCM in egg extracts of Xenopus laevis ... High cyclin E kinase activity allows the binding of Xenopus ORC and Cdc6, but not MCM, to sperm chromatin, even though the kinase does not phosphorylate MCM directly
Hossain et al., Genes Dev 2012 (Growth Disorders...) : A cyclin binding motif (Cy motif) is required for Orc1 to bind Cyclin A and inhibit Cyclin A-CDK2 kinase activity but has no effect on Cyclin E-CDK2 kinase activity ... In contrast, Orc1 inhibition of Cyclin E-CDK2 kinase activity occurs by a different mechanism that is affected by Orc1 mutations identified in Meier-Gorlin syndrome patients